Scientist II: Non-Viral Gene Insertion Delivery

Profluent; Emeryville (CA); On-site; USD 144,000 - 160,000; Full time

Benefits offered by this job

Equity participation

401(k) with employer match

Generous PTO

Job summary

Profluent is seeking a Scientist II to advance non-viral delivery methods for recombinase-based large gene insertion in mammalian cells. You will lead experiments, analyze data, and collaborate across AI and biology teams to enable new therapeutic opportunities.

The role requires a PhD with 2–4 years of relevant experience and a proven track record in gene editing or related areas. An equity-inclusive compensation package and strong professional development are offered.

Qualifications

• PhD in molecular biology, biochemistry, bioengineering, or related field with 2–4 years of experience.
• Proven track record in gene editing, in vivo delivery, or protein engineering.
• Strong hands-on experience with nucleic acid delivery and mammalian cell engineering.

Responsibilities

• Lead development and benchmarking of non-viral donor template delivery for recombinase-based large gene insertion.
• Design hypothesis-driven experiments to improve donor template stability and nuclear availability.
• Develop quantitative assays to measure delivery efficiency and fidelity; connect to outcomes.
• Analyze data and present conclusions to stakeholders across the organization.
• Collaborate with translational teams to validate delivery approaches in relevant systems.
• Stay updated on gene editing delivery developments and cellular models.
• Mentor junior team members to align goals and ensure rigorous execution.

Skills

Gene editing

Non-viral delivery

Mammalian cell engineering

NGS-based assays

Education

PhD in molecular biology

Tools

Molecular cloning

Nucleic acid design

Job description

Profluent is seeking a Scientist II to advance non-viral delivery methods for recombinase-based large gene insertion in mammalian cells. You will lead experiments, analyze data, and collaborate across AI and biology teams to enable new therapeutic opportunities.

The role requires a PhD with 2–4 years of relevant experience and a proven track record in gene editing or related areas. An equity-inclusive compensation package and strong professional development are offered.