Scientist II, Gene Insertion (CRISPR-X) — Onsite + Equity

Crispr-Therapeutics-1; Boston (MA); On-site; USD 130,000 - 140,000; Full time

Job summary

CRISPR Therapeutics is seeking a Scientist II to grow our CRISPR-X team and advance next‑gen gene editing therapies for human disease. You will design and execute research using molecular biology, CAR T, and immune-oncology approaches, contributing to a broad clinical portfolio.

The role emphasizes hands-on development of genome editing modalities, collaboration across teams, and on-site manufacturing activities. Excellent problem solving and scientific rigor are essential.

Qualifications

• Ph.D. in biology, bioengineering, immunology, or related discipline with 2-5+ years of professional experience, or non-PhD and 10-12+ years of progressive, relevant experience.
• Experience with gene editing technologies and advancing next-generation gene editing approaches.
• Hands-on experience with CAR T cell engineering including construct design and functional characterization.

Responsibilities

• Lead, design, and optimize research exploring next-generation gene editing strategies and immunology.
• Design, execute, and interpret research using cloning, qPCR/ddPCR, NGS, RNA/DNA analysis, and cell culture.
• Guide construct design and interpretation of in-vivo CAR T and immune studies.
• Develop translational assays to evaluate gene editing and CAR approaches across in-vitro and in-vivo systems.

Skills

Gene editing

CAR T cell engineering

Molecular biology

Cloning

qPCR/ddPCR

NGS

Education

Ph.D. in biology, bioengineering, immunology, or related field

2-5+ years of professional experience (or 10-12+ for non-PhD)

Tools

qPCR

NGS

Cell culture

Job description

CRISPR Therapeutics is seeking a Scientist II to grow our CRISPR-X team and advance next‑gen gene editing therapies for human disease. You will design and execute research using molecular biology, CAR T, and immune-oncology approaches, contributing to a broad clinical portfolio.

The role emphasizes hands-on development of genome editing modalities, collaboration across teams, and on-site manufacturing activities. Excellent problem solving and scientific rigor are essential.