Scientist II, Metabolomics & Lipidomics—Mass Spec Innovator

Genentech, Inc.; San Francisco (CA); On-site; USD 86,000 - 159,000; Full time

Job summary

Genentech, Inc. in South San Francisco is seeking a Scientist II to advance biomarker workflows using LC-MS, with AI-assisted data analysis. You will contribute to target biology evaluation and drug discovery in a collaborative, high-impact environment.

The role requires a Bachelor’s or Master’s with 3–5+ years in biotech/pharma, expertise in LC-MS, sample prep, and data interpretation. On-site, with a competitive salary and discretionary bonus; relocation not offered.

Qualifications

• Bachelor’s or Master’s degree in biological, chemical, pharmaceutical sciences, or related field, with 3–5 years (Master’s) or 5+ years (Bachelor’s) of biotech/pharma experience.
• Proven LCMS assays for endogenous small molecules or lipids; includes protein precipitation, liquid-liquid extraction or solid-phase extraction.
• Experience operating and troubleshooting modern LC-MS platforms (UHPLC, QQ, HRMS) and using data processing software.

Responsibilities

• Perform onsite LC-MS workflows to acquire biomarker data for target biology and drug discovery.
• Use liquid handling automation for sample prep and extraction across diverse specimens.
• Process MS data and run in-house AI/ML workflows to scale analysis and reporting.
• Maintain quality records and comply with safety and lab standards.

Skills

LC-MS workflows

Mass spec workflows

Generative AI

Team collaboration

Education

Bachelor’s in biological/chemical/pharma sciences

Master’s in related field

Tools

UHPLC

Triple quadrupole

High-resolution MS

Job description

Genentech, Inc. in South San Francisco is seeking a Scientist II to advance biomarker workflows using LC-MS, with AI-assisted data analysis. You will contribute to target biology evaluation and drug discovery in a collaborative, high-impact environment.

The role requires a Bachelor’s or Master’s with 3–5+ years in biotech/pharma, expertise in LC-MS, sample prep, and data interpretation. On-site, with a competitive salary and discretionary bonus; relocation not offered.