Scientist II

Genentech; San Francisco (CA); On-site; USD 86,000 - 159,000; Full time

Job summary

Genentech, Inc. in South San Francisco is seeking a Scientist II to advance biomarker workflows using LC-MS, with AI-assisted data analysis. You will contribute to target biology evaluation and drug discovery in a collaborative, high-impact environment.

The role requires a Bachelor’s or Master’s with 3–5+ years in biotech/pharma, expertise in LC-MS, sample prep, and data interpretation. On-site, with a competitive salary and discretionary bonus; relocation not offered.

Qualifications

• Bachelor’s or Master’s degree in biological, chemical, pharmaceutical sciences, or related field, with 3–5 years (Master’s) or 5+ years (Bachelor’s) of biotech/pharma experience.
• Proven LCMS assays for endogenous small molecules or lipids; includes protein precipitation, liquid-liquid extraction or solid-phase extraction.
• Experience operating and troubleshooting modern LC-MS platforms (UHPLC, QQ, HRMS) and using data processing software.

Responsibilities

• Perform onsite LC-MS workflows to acquire biomarker data for target biology and drug discovery.
• Use liquid handling automation for sample prep and extraction across diverse specimens.
• Process MS data and run in-house AI/ML workflows to scale analysis and reporting.
• Maintain quality records and comply with safety and lab standards.

Skills

LC-MS workflows

Mass spec workflows

Generative AI

Team collaboration

Education

Bachelor’s in biological/chemical/pharma sciences

Master’s in related field

Tools

UHPLC

Triple quadrupole

High-resolution MS

Job description

The Position

Scientist II

As a Scientist II in the Small Molecule Biomarkers (Metabolomics & Lipidomics) team within our Drug Metabolism and Pharmacokinetics (DMPK) department, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by executing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.

This position is based in South San Francisco, on site.

Key Responsibilities

• Experimental Execution: Routinely perform onsite lab-based LC-MS workflow methods to acquire high-quality mass spectrometry biomarker data supporting target biology evaluation, drug discovery and development.
• Automation: Use liquid handling automation to execute automated sample preparation workflows, including protein precipitation, liquid-liquid and solid-phase extraction, and chemical derivatization. Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
• Data & AI Workflows: Execute mass spectrometry data processing and statistical analysis leveraging in-house AI/ML workflows and commercial software tools to scale analysis and reporting.
• Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.Organize and document accurate experimental records following the guidance of lead scientists to support the timely delivery of high-quality data and study reports.
• Support routine lab operations including instrument maintenance, consumable and chemical management, and compliance with lab safety and quality standards.

Who You Are

You are an innovative analytical Lab scientist with a passion for biochemistry, cellular metabolism, small molecule biomarkers, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.

Qualifications & Experience

• Education & Industry Experience: Bachelor’s or Master’s degree in biological, chemical, pharmaceutical sciences, or a related field, accompanied by at least 5 years ( Bachelor’s) or at least 3 years (Master’s) of direct experience in the biotechnology or pharmaceutical industry.
• Bioanalytical Expertise: Proven experience in executing LCMS assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like protein precipitation, liquid-liquid, or solid-phase extraction.
• Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
• Metabolic & Computational Insight: Solid foundation in biochemistry, cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding
• Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of California is 85500,00 - 158700,00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.