Scientist, Gene Editing Sciences & Laboratory Operations

MaxCyte, Inc.; Waltham (MA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Health, dental, vision insurance

Disability insurance

Generous time off

Job summary

MaxCyte, Inc. in Waltham, MA, is seeking a Scientist to support research, development, and lab operations within the Gene Editing Sciences team. You will contribute to genomic safety assay development, validation, and data generation in a regulated environment.

The role includes optimizing workflows, performing mammalian cell culture and CRISPR editing, and collaborating with internal teams and clients to advance CRISPR therapies.

Qualifications

• Ph.D. in molecular biology, genomics, or related field, with 0–2 years of relevant research experience; or B.S./M.S with 4–6 years.
• Experience in genomics techniques including NGS and gene editing off-target methodologies.
• Proficiency with primer design, PCR, qPCR, ddPCR, and nucleic acid purification.
• Experience with primary human cell culture and in vitro study design including cell sorting and imaging.

Responsibilities

• Execute genomic safety assessment strategies for gene editing therapeutics and analyze data.
• Lead development, optimization, validation, transfer, and implementation of genomic safety assays.
• Interpret and present data to internal teams, clients, and stakeholders.
• Maintain current knowledge of gene editing, sequencing technologies, and regulatory expectations.
• Maintain mammalian cell culture and perform CRISPR-based editing.

Skills

Genomics techniques

CRISPR off-target

Molecular skills

Cell culture

Data interpretation

Education

Ph.D. in molecular biology/genomics

B.S./M.S. with 4-6 years of experience

Tools

NGS sequencers

PCR/qPCR/ddPCR

Automated liquid handlers

Job description

About the Role:

MaxCyte's SeQure platform applies state-of-the-art genomics technologies for CRISPR gene editing target profiling to advance discovery, clinical development, and diagnostic solutions. Our technologies provide the foundation needed to ensure that gene editing therapies are both safe and effective. This is an exciting opportunity to join a multidisciplinary team operating at the forefront of gene editing innovation and genomic safety assessment.

Description

We are seeking a highly motivated Scientist to support both research and development activities and laboratory operations within the Gene Editing Sciences team. The successful candidate will contribute to the development, validation, and execution of genomic safety assessment assays while ensuring efficient laboratory operations and high-quality data generation in a regulated environment. This individual will play a key role in evaluating emerging genome engineering technologies, implementing new workflows, supporting client studies, and driving continuous process improvement.

About the Role:

MaxCyte's SeQure platform applies state-of-the-art genomics technologies for CRISPR gene editing target profiling to advance discovery, clinical development, and diagnostic solutions. Our technologies provide the foundation needed to ensure that gene editing therapies are both safe and effective. This is an exciting opportunity to join a multidisciplinary team operating at the forefront of gene editing innovation and genomic safety assessment.

Key Responsibilities

Scientific Research and Assay Development

• Execute genomic safety assessment strategies for gene editing therapeutics, including off-target discovery, confirmation, genome integrity characterization, and assessment of editing outcomes.
• Lead the development, optimization, validation, transfer, and implementation of genomic safety assessment assays and technologies.
• Analyze, interpret, and present scientific data to internal teams, clients, and external stakeholders.
• Stay current with advances in gene editing, genomics, sequencing technologies, and regulatory expectations.
• Maintain mammalian cell culture, and perform and optimize CRISPR-based cell editing using various approaches.

Laboratory Operations & Study Execution

• Execute complex molecular biology and NGS workflows including sample preparation, PCR, library preparation, sequencing, and quality control.
• Operate, maintain, troubleshoot, and qualify laboratory instrumentation, including automated liquid handlers, NGS sequencers, and associated molecular biology equipment.
• Manage multiple studies and priorities while ensuring high standards of data quality, documentation, and timely project execution.
• Serve as a technical expert for laboratory operations, assay execution, and scientific problem-solving.

Quality & Continuous Improvement

• Author and maintain SOPs, protocols, training materials, validation documents, and investigation records.
• Support quality events, deviations, nonconformances, and CAPA activities through root cause analysis and effective resolution.
• Drive continuous improvement through workflow optimization, automation, inventory management, and laboratory scalability initiatives.
• Train and mentor junior scientists and contribute to building operational capabilities that support organizational growth.

Requirements

• Ph.D. in molecular biology, genomics, or related field with 0-2 years of relevant research experience. B.S./M.S plus 4-6 years of relevant research experience
• Experience in genomics techniques including next generation sequencing, chromosomal rearrangement detection, and gene editing off-target methodology
• Proficiency in molecular skills, including primer design, PCR, qPCR, ddPCR, and nucleic acid purification
• Proficiency with primary human cell culture and cell-based in vitro study design and optimization including cell sorting, imaging, and fluorescence-based readout

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.