Scientist, Immunology and Non-viral engineering

MaxCyte, Inc; Rockville (MD); On-site; USD 110,000 - 145,000; Full time

Benefits offered by this job

Equity

Annual bonus

Health insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

Generous paid time off

Job summary

MaxCyte, Inc is seeking a Scientist in Immunology & Non-viral Engineering to develop non-viral gene editing workflows in primary and immune cells using CRISPR/Cas, RNPs, mRNA, and DNA templates. You will engineer T cells, NK cells, and macrophages, assess editing outcomes, and work with cross-functional teams to advance internal R&D and platform innovation.

The role emphasizes data quality, regulatory alignment, and collaboration with Field Application Scientists for customer-supported

Qualifications

• PhD or Master’s with substantial hands-on experience in non-viral gene editing.
• Strong background in immune cell biology including isolation and activation.
• Proficiency in flow cytometry and immune phenotyping design.
• Hands-on experience with electroporation-based delivery and non-viral delivery of gene editing reagents.

Responsibilities

• Design and execute non-viral gene editing workflows using CRISPR/Cas, RNPs, mRNA, and DNA templates.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess editing efficiency and function.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays.
• Analyze flow cytometry, NGS, and molecular data and prepare summaries for teams and partners.
• Collaborate with project management to ensure timely delivery of materials and results.
• Provide scientific support to customer-facing teams including remote and onsite troubleshooting.

Skills

Flow cytometry

Immune cell biology

Non-viral gene editing

CRISPR/Cas

RNPs

Data analysis

Gene delivery

Education

PhD in Immunology or related field

Master’s with 5+ years hands-on experience

Tools

Electroporation delivery

High-throughput screening

Automation tooling

Job description

Description

The Scientist, Immunology & Non-viral engineering will support MaxCyte’s mission by developing and executing non-viral engineering workflows for immune cells using the company’s electroporation technology. This role combines immunology expertise with hands-on gene editing experience to generate high-quality data that advances internal R&D programs, customer collaborations, and platform innovation. The scientist will work cross-functionally to ensure scientific rigor, operational excellence, and alignment with MaxCyte’s non-viral engineering capabilities.

• Design and execute non-viral gene editing workflows using CRISPR/Cas systems, RNPs, mRNA, and DNA templates in primary cells and cell lines.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess editing efficiency, viability, and functional outcomes.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays to characterize engineered cells.
• Analyze flow cytometry, NGS, and molecular assay data; prepare clear summaries for internal teams and external partners.
• Apply deep understanding of MaxCyte’s non-viral delivery technology to optimize workflows and troubleshoot experiments.
• Design, perform, and troubleshoot laboratory experiments in accordance with established protocols, quality standards, and regulatory expectations.
• Analyze and interpret experimental data, prepare technical summaries, and present results to internal and external stakeholders.
• Collaborate with project management teams to ensure alignment and timely delivery of materials.
• Provide scientific support to customer-facing teams, including remote and onsite troubleshooting with Field Application Scientists.
• Evaluate and implement new technologies, automation tools, and high-throughput approaches to increase efficiency and scalability.
• Contribute to internal innovation initiatives, including development of new products, platform enhancements, and scientific capability expansion.
• Maintain accurate, complete, and compliant laboratory records.
• Ensure adherence to organizational, regulatory, and safety standards.

Requirements

• PhD in Immunology, Molecular Biology, Cell Biology, or related field with 2-3+ years or Master’s degree with 5+ years of with hands-on experience with non-viral gene editing, including CRISPR/Cas RNPs, mRNA, or DNA template delivery.
• Strong background in immune cell biology, including isolation, activation.
• Proficiency in flow cytometry, multi-color panel design, and immune phenotyping.
• Hands-on experience with electroporation-based delivery or non-viral delivery of gene editing reagents.
• Hands- on experience with high-throughput screening, automation, or advanced analytical tools.
• Ability to work effectively in a structured, fast-paced, milestone-driven industry or core laboratory environment.
• Hands-on experience with cell therapy development, including CAR-T, TCR, NK, DC or macrophage engineering.
• Familiarity with base editing, prime editing, or emerging non-viral modalities.
• Good communication skills and ability to work collaboratively with internal team members and customers.

MaxCyte offers a base salary, annual bonus, and equity.

• MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer.

All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status.