Scientist, Immunology and Non-viral engineering

MaxCyte, Inc.; Rockville (MD); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Base salary

Annual bonus

Equity

Health, dental, vision

Job summary

MaxCyte, Inc. is seeking a Scientist, Immunology & Non-viral engineering to design and execute non-viral gene editing workflows in primary human immune cells and cell lines.

You will apply CRISPR/Cas systems, RNPs, mRNA, and DNA templates to advance internal R&D programs and customer collaborations using MaxCyte's electroporation platform. In this role you will optimize workflows, analyze data from flow cytometry and sequencing, and collaborate with cross-functional teams to deliver high-quality

Qualifications

• PhD with 2-3+ years hands-on non-viral gene editing experience (CRISPR/Cas RNPs, mRNA, or DNA templates).
• Strong immune cell biology background including isolation and activation.
• Proficiency in flow cytometry and immune phenotyping with multi-color panels.
• Experience with electroporation-based delivery and non-viral gene editing.
• Experience with high-throughput screening, automation, or advanced analytics.
• Excellent communication and collaboration skills.

Responsibilities

• Design and execute non-viral gene editing workflows in primary cells and cell lines.
• Engineer T cells, NK cells, macrophages; assess editing efficiency and viability.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping.
• Analyze flow cytometry, NGS, and molecular data; summarize results for teams.
• Optimize workflows and troubleshoot experiments with non-viral delivery tech.
• Design, perform, and troubleshoot lab experiments per protocols and safety standards.
• Collaborate with project management to ensure timely material delivery.
• Provide scientific support to customer-facing teams (remote and onsite).
• Evaluate new tech, automation, high-throughput approaches to increase efficiency.
• Contribute to internal innovation initiatives and platform enhancements.
• Maintain compliant laboratory records and adhere to standards.

Skills

CRISPR/Cas RNPs

mRNA & DNA templates

Flow cytometry

Immune cell biology

Electroporation delivery

High-throughput screening

Cell therapy development

Education

PhD in Immunology/Related field

MS in related field +5 years experience

Tools

Flow cytometer

NGS

Automation tools

Job description

Description

The Scientist, Immunology & Non-viral engineering will support MaxCyte's mission by developing and executing non-viral engineering workflows for immune cells using the company's electroporation technology. This role combines immunology expertise with hands-on gene editing experience to generate high-quality data that advances internal R&D programs, customer collaborations, and platform innovation. The scientist will work cross-functionally to ensure scientific rigor, operational excellence, and alignment with MaxCyte's non-viral engineering capabilities.

• Design and execute non-viral gene editing workflows using CRISPR/Cas systems, RNPs, mRNA, and DNA templates in primary cells and cell lines.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess editing efficiency, viability, and functional outcomes.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays to characterize engineered cells.
• Analyze flow cytometry, NGS, and molecular assay data; prepare clear summaries for internal teams and external partners.
• Apply deep understanding of MaxCyte's non-viral delivery technology to optimize workflows and troubleshoot experiments.
• Design, perform, and troubleshoot laboratory experiments in accordance with established protocols, quality standards, and regulatory expectations.
• Analyze and interpret experimental data, prepare technical summaries, and present results to internal and external stakeholders.
• Collaborate with project management teams to ensure alignment and timely delivery of materials.
• Provide scientific support to customer-facing teams, including remote and onsite troubleshooting with Field Application Scientists.
• Evaluate and implement new technologies, automation tools, and high-throughput approaches to increase efficiency and scalability.
• Contribute to internal innovation initiatives, including development of new products, platform enhancements, and scientific capability expansion.
• Maintain accurate, complete, and compliant laboratory records.
• Ensure adherence to organizational, regulatory, and safety standards.

Description

The Scientist, Immunology & Non-viral engineering will support MaxCyte's mission by developing and executing non-viral engineering workflows for immune cells using the company's electroporation technology. This role combines immunology expertise with hands-on gene editing experience to generate high-quality data that advances internal R&D programs, customer collaborations, and platform innovation. The scientist will work cross-functionally to ensure scientific rigor, operational excellence, and alignment with MaxCyte's non-viral engineering capabilities.

• Design and execute non-viral gene editing workflows using CRISPR/Cas systems, RNPs, mRNA, and DNA templates in primary cells and cell lines.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess editing efficiency, viability, and functional outcomes.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays to characterize engineered cells.
• Analyze flow cytometry, NGS, and molecular assay data; prepare clear summaries for internal teams and external partners.
• Apply deep understanding of MaxCyte's non-viral delivery technology to optimize workflows and troubleshoot experiments.
• Design, perform, and troubleshoot laboratory experiments in accordance with established protocols, quality standards, and regulatory expectations.
• Analyze and interpret experimental data, prepare technical summaries, and present results to internal and external stakeholders.
• Collaborate with project management teams to ensure alignment and timely delivery of materials.
• Provide scientific support to customer-facing teams, including remote and onsite troubleshooting with Field Application Scientists.
• Evaluate and implement new technologies, automation tools, and high-throughput approaches to increase efficiency and scalability.
• Contribute to internal innovation initiatives, including development of new products, platform enhancements, and scientific capability expansion.
• Maintain accurate, complete, and compliant laboratory records.
• Ensure adherence to organizational, regulatory, and safety standards.

Requirements

• PhD in Immunology, Molecular Biology, Cell Biology, or related field with 2-3+ years or Master's degree with 5+ years of with hands-on experience with non-viral gene editing, including CRISPR/Cas RNPs, mRNA, or DNA template delivery.
• Strong background in immune cell biology, including isolation, activation.
• Proficiency in flow cytometry, multi-color panel design, and immune phenotyping.
• Hands-on experience with electroporation-based delivery or non-viral delivery of gene editing reagents.
• Hands-on experience with high-throughput screening, automation, or advanced analytical tools.
• Ability to work effectively in a structured, fast-paced, milestone-driven industry or core laboratory environment.
• Hands-on experience with cell therapy development, including CAR-T, TCR, NK, DC or macrophage engineering.
• Familiarity with base editing, prime editing, or emerging non-viral modalities.
• Good communication skills and ability to work collaboratively with internal team members and customers.

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status