Scientist, Immunology and Non-viral engineering

SeQure DX; Rockville (MD); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Base salary

Annual bonus

Equity

Benefits package

Generous time off

Job summary

MaxCyte is seeking a Scientist, Immunology & Non-viral engineering to advance non-viral workflows for immune cells using electroporation technology. This role blends immunology expertise with hands-on gene editing to generate high-quality data that supports internal R&D, customer collaborations, and platform innovation.

You will design CRISPR/Cas, engineer T and NK cells, perform activation and profiling assays, and analyze data to deliver clear insights for internal teams and external partners.

Qualifications

• PhD in immunology or related field with 2–3+ years hands-on non-viral gene editing experience.
• Strong background in immune cell biology, including isolation and activation.
• Proficiency in flow cytometry and immune phenotyping.
• Hands-on experience with electroporation-based delivery or non-viral delivery of gene editing reagents.
• Hands-on experience with high-throughput screening, automation, or advanced analytics.
• Ability to work in a structured, fast-paced, milestone-driven lab and collaborate cross-functionally.
• Experience in cell therapy development (CAR-T, TCR, NK, DC or macrophage engineering).

Responsibilities

• Design and execute non-viral gene editing workflows using CRISPR/Cas systems, RNPs, mRNA, and DNA templates.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess outcomes.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays.
• Analyze flow cytometry, NGS, and molecular data and present results to teams.
• Collaborate with project teams to ensure timely delivery of materials.
• Provide scientific support to customer-facing teams with remote and onsite troubleshooting.
• Evaluate new technologies and automation to increase efficiency and scalability.
• Maintain accurate, compliant laboratory records and adhere to safety standards.

Skills

Immunology

Flow cytometry

Non-viral gene editing

Cell culture

Data analysis

Education

PhD in Immunology

Master's in related field

Tools

CRISPR/Cas RNPs

mRNA delivery

DNA templates

Electroporation

NGS

Job description

Job Type

Full-time

Description

The Scientist, Immunology & Non-viral engineering will support MaxCyte’s mission by developing and executing non-viral engineering workflows for immune cells using the company’s electroporation technology. This role combines immunology expertise with hands-on gene editing experience to generate high-quality data that advances internal R&D programs, customer collaborations, and platform innovation. The scientist will work cross-functionally to ensure scientific rigor, operational excellence, and alignment with MaxCyte’s non-viral engineering capabilities.

• Design and execute non-viral gene editing workflows using CRISPR/Cas systems, RNPs, mRNA, and DNA templates in primary cells and cell lines.
• Engineer primary human immune cells (T cells, NK cells, macrophages) and assess editing efficiency, viability, and functional outcomes.
• Perform activation, proliferation, cytokine profiling, cytotoxicity, and phenotyping assays to characterize engineered cells.
• Analyze flow cytometry, NGS, and molecular assay data; prepare clear summaries for internal teams and external partners.
• Apply deep understanding of MaxCyte’s non-viral delivery technology to optimize workflows and troubleshoot experiments.
• Design, perform, and troubleshoot laboratory experiments in accordance with established protocols, quality standards, and regulatory expectations.
• Analyze and interpret experimental data, prepare technical summaries, and present results to internal and external stakeholders.
• Collaborate with project management teams to ensure alignment and timely delivery of materials.
• Provide scientific support to customer-facing teams, including remote and onsite troubleshooting with Field Application Scientists.
• Evaluate and implement new technologies, automation tools, and high-throughput approaches to increase efficiency and scalability.
• Contribute to internal innovation initiatives, including development of new products, platform enhancements, and scientific capability expansion.
• Maintain accurate, complete, and compliant laboratory records.
• Ensure adherence to organizational, regulatory, and safety standards.

Requirements

• PhD in Immunology, Molecular Biology, Cell Biology, or related field with 2-3+ years or Master’s degree with 5+ years of with hands-on experience with non-viral gene editing, including CRISPR/Cas RNPs, mRNA, or DNA template delivery.
• Strong background in immune cell biology, including isolation, activation.
• Proficiency in flow cytometry, multi-color panel design, and immune phenotyping.
• Hands-on experience with electroporation-based delivery or non-viral delivery of gene editing reagents.
• Hands- on experience with high-throughput screening, automation, or advanced analytical tools.
• Ability to work effectively in a structured, fast-paced, milestone-driven industry or core laboratory environment.
• Hands-on experience with cell therapy development, including CAR-T, TCR, NK, DC or macrophage engineering.
• Familiarity with base editing, prime editing, or emerging non-viral modalities.
• Good communication skills and ability to work collaboratively with internal team members and customers.

MaxCyte offers a base salary, annual bonus, and equity. MaxCyte also offers a comprehensive benefits package including health, dental, vision, life, and disability insurance and generous time off.

MaxCyte is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex, sexual orientation, gender identity, religion, national origin, disability, veteran status, age, marital status, pregnancy, genetic information, or other legally protected status