Scientist Bioscience - Proteomics

Global-Technical-Talent-1; Cambridge (MA); On-site; USD 55,000 - 66,000; Full time

Benefits offered by this job

Medical, Vision, and Dental Insurance

401k Retirement Fund

Job summary

Global-Technical-Talent-1 is seeking a Scientist Bioscience - Proteomics in Cambridge, MA for a 12-month contract role within Discovery Sciences. You will apply proteomics to advance drug discovery, interrogate mechanisms of action, and validate hypotheses in CVRM contexts.

The role emphasizes hands-on MS-based proteomics, cell culture, and data interpretation within a collaborative CBP team.

Qualifications

• Hands-on proteomics experience from graduate, postdoctoral, or industry work.
• Experience with proteomic sample preparation and mammalian cell culture.
• Experience applying proteomics to understand small molecule mechanisms of action.
• Ability to work independently and within cross-functional teams.

Responsibilities

• Design and execute discovery proteomic assays using mass spectrometry to support mechanistic studies.
• Perform proximity biotinylation studies with established workflows and DIA MS methods.
• Validate targets with proximity ligation assays and cell-based assays.
• Generate protein conjugates and characterize labeling by UV-Vis spectroscopy.
• Analyze data with bioinformatic pipelines and maintain notebooks.
• Communicate results and contribute to mechanistic hypotheses.

Skills

Proteomics

Mammalian cell culture

Data analysis

Proteomic sample preparation

Small molecule MOA studies

Independent & collaborative work

Mass spectrometry workflows

Affinity enrichment proteomics

Education

PhD in Proteomics/related

Master's with proteomics experience

Tools

LC-MS/MS platforms

Semi-automated instrumentation

Job description

Scientist Bioscience - Proteomics

Location: Cambridge, MA

Onsite Flexibility: Onsite

Contract Details

• Position Type: Contract
• Contract Duration: 12 months
• Pay Rate: $40.00–$48.00 / Hour (USD)
• Work Authorization: Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Job Summary

We are seeking a highly motivated and talented scientist to join a global biopharmaceutical organization's Chemical Biology and Proteomics group within Discovery Sciences. As a Research Scientist on a 12-month fixed-term contract, you will apply proteomics to advance drug discovery. You will work as an integral member of a cross-functional team to interrogate mechanisms of action for therapeutic agents, and to propose and validate biological hypotheses for agents within the cardiovascular, renal and metabolism (CVRM) area. If you're inspired by the possibilities of science to make a difference and ready to discover what you can do join us.

Key Responsibilities

• Design and execute discovery proteomic assays using mass spectrometry to support mechanistic studies, identify targets, and elucidate biological regulators of disease biology.
• Perform proximity biotinylation studies in cells, using established automated affinity purification workflows and data-independent acquisition (DIA) mass spectrometry methods.
• Perform target validation by developing proximity ligation assays (PLA) and cell-based assays to assess protein-protein interactions using chemical tools and confocal microscopy.
• Generate protein conjugates and characterize protein labeling by UV-Vis spectroscopy.
• Analyze and interpret experimental data using established bioinformatic pipelines.
• Maintain detailed and accurate electronic laboratory notebooks.
• Represent the CBP team, communicate with project discipline leads, and contribute to the generation of mechanistic hypotheses through interpretation of proteomics data.

Required Skills

• Hands-on proteomics experience (from graduate, postdoctoral, or industry work)
• Mammalian cell culture
• Data analysis
• Knowledge and hands-on experience with proteomic sample preparation
• Experience employing cell-based and proteomic assays to understand small molecule mechanisms of action
• Demonstrated ability to work effectively both independently and collaboratively, contribute to scientific discussions, solve problems, and deliver high-quality results within agreed timelines
• Similar workflows including mammalian cell culture, protein conjugation, purification, and UV-Vis spectroscopy characterization
• Affinity enrichment proteomics and mass spectrometry: carrying out advanced mass spectrometry-based proteomics with affinity enrichments
• Expected to operate with significantly higher independence than the Associate Scientist

Preferred Skills

• Experience developing or applying proximity ligation assays or related proximity-based protein-protein interaction validation assays
• Experience using LC-MS/MS platforms and semi-automated instrumentation
• Experience using proteomics search and analysis tools, such as Spectronaut, Proteome Discoverer, MaxQuant, Skyline, and Xcalibur

Education Requirements

• Ph.D. in Proteomics, Chemical Biology, Biological Sciences, Biochemistry, or a related discipline, with at least two years of hands‑on proteomics experience, including experience gained during doctoral or postdoctoral research
• OR a Master's degree with 3–5 years of hands‑on proteomics experience (minimum 1 year of industry proteomics experience)

Required Experience

• Hands-on proteomics experience is mandatory (from graduate, postdoctoral, or industry work)
• Experience in mammalian cell culture
• Ph.D. candidates: at least two years of hands‑on proteomics experience, including experience gained during doctoral or postdoctoral research
• Master's degree candidates: minimum 1 year of industry proteomics experience and 3–5 years of hands‑on lab experience

Benefits

• Medical, Vision, and Dental Insurance Plans
• 401k Retirement Fund

About the Client

This global biopharmaceutical company operates with a single defining mission: to push the boundaries of science and deliver life-changing medicines that transform the lives of patients worldwide. With a footprint spanning more than 100 countries, the organization focuses on three core therapy areas oncology, cardiovascular and metabolic disease, and respiratory and immunology, while also advancing treatments in rare diseases and vaccines. The pipeline is consistently regarded as one of the most productive in the industry, combining the resource depth of a top-tier pharma company with a genuine culture of scientific curiosity.

Employing tens of thousands of scientists, clinicians, and business professionals globally, the organization's research programs span small molecules, biologics, cell therapy, and RNA technologies, giving employees exposure to the full frontier of modern drug development. In 2026, employees voted this organization onto Glassdoor's Best Places to Work list, and it holds an overall Glassdoor rating of 4.0 stars from nearly 8,000 reviews, with 79% of employees saying they would recommend working here to a friend.

The organization has built a strong reputation for scientific career development, with structured pathways for researchers, clinical professionals, and commercial staff. Teams here span oncology researchers, clinical trial specialists, regulatory scientists, and commercial and market access professionals.

Job Number: 26-15979

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