Associate Scientist Discovery Proteomics

Initial Therapeutics, Inc.; South San Francisco (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

Amgen is seeking an Associate Scientist Discovery Proteomics in South San Francisco to expand expertise in LC-MS/MS-based proteomics and support early discovery programs. You will execute workflows for quantitative proteomics, including cell-surface target discovery, proximity labeling, and biomarker efforts, collaborating with colleagues across biology, automation and bioinformatics.

The role involves maintaining rigorous data integrity, interpreting results, and communicating plans to

Qualifications

• Master's degree in analytical chemistry, biochemistry, chemical biology, molecular/cell biology, or related field.
• Hands-on proteomics sample preparation experience.
• Familiarity with Proteome Discoverer, Spectronaut, DIA-NN or similar software.
• Experience with LC-MS workflows and data interpretation.

Responsibilities

• Execute and optimize established proteomics workflows including sample prep and LC-MS acquisition.
• Prepare samples from cell lines and biological matrices using enrichment workflows.
• Operate LC-MS systems across vendor platforms and troubleshoot issues.
• Process proteomic data and communicate results to project teams.
• Maintain detailed records of experiments and instrument performance.

Education

Masters degree

Bachelors degree + 2 years experience

Associates degree + 4 years experience

High school diploma / GED + 6 years experience

Tools

Proteome Discoverer

Spectronaut

DIA-NN

LC-MS systems

Proximity labeling

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Associate Scientist Discovery Proteomics

What you will do

Lets do this. Lets change the world. In this vital role you will expand your experience in liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to work in South San Francisco. The team develops and applies proteomic technologies to support Amgens early discovery pipeline programs and technology platforms. In this role, the Associate Scientist will execute and optimize quantitative proteomic workflows supporting cell-surface target discovery, proximity-labeling studies, preclinical biomarker discovery, and mechanism-of-action investigations. The successful candidate will work closely with proteomics, functional genomics, biology, automation, and bioinformatics colleagues to generate high-quality, reproducible data and communicate results to project teams.

This lab-based role will support Amgens preclinical pipeline through high-quality experimental execution and collaborative problem solving. Responsibilities will include:

• Execute and optimize established proteomics workflows, including sample preparation, peptide fractionation, liquid chromatography, and mass spectrometry acquisition for discovery and targeted approaches such as DIA, TMT, label-free DDA and PRM.
• Prepare samples from cell lines and other biological matrices using workflows such as cell-surface protein enrichment and proximity labeling.
• Operate LC-MS systems across several vendor platforms, assess instrument and data quality, perform routine maintenance, and troubleshoot common workflow or instrument issues with guidance from senior staff.
• Process and evaluate proteomic data using software such as Proteome Discoverer, Spectronaut, and DIA-NN, and work with bioinformatics and senior colleagues to support data analysis and sharing.
• Analyze results and identify technical issues in collaboration with project scientists.
• Communicate experimental plans, progress, and results to immediate team members and cross-functional collaborators.
• Maintain detailed and accurate records of experiments, protocols, instrument performance, and analyses in accordance with laboratory and data-integrity practices.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The] professional we seek is a scientist with these qualifications.

Basic Qualifications:

• Masters degree
• Bachelors degree and 2 years of scientific experience
• Associates degree and 4 years of scientific experience
• High school diploma / GED and 6 years of scientific experience

Preferred Qualifications:

• Bachelors, Masters, or PhD degree in analytical chemistry, biochemistry, chemical biology, molecular or cell biology, or related discipline.
• Hands-on experience with proteomic sample preparation.
• Familiarity with Proteome Discoverer, Spectronaut, DIA-NN, or similar proteomics software and the ability to assess data quality and interpret results.
• Experience with protein enrichment methods is desirable.
• Ability to evaluate LC-MS performance and troubleshoot routine sample-preparation, chromatography, or instrument issues.
• Experience with automated sample-preparation platforms, such as Tecan, Hamilton, Opentrons, or KingFisher, is a plus.
• Experience working with diverse biological sample types, including cell lines, tissues, biofluids, and FFPE specimens, is also preferred.
• Strong organizational, communication, and interpersonal skills, with attention to detail and a commitment to reliable, reproducible results.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.