RCI-AZN-33034 Associate Proteomics Scientist

Rangam; Cambridge (MA); On-site; USD 65,000 - 95,000; Full time

Job summary

Rangam, Cambridge, MA, seeks a contract Associate Scientist to join the Chemical Biology and Proteomics group within Discovery Sciences. The role is a 12-month assignment with potential extension, focusing on applying proteomics to advance drug discovery.

You will design and execute discovery proteomic screens using mass spectrometry, perform proximity biotinylation studies in cells, generate protein conjugates, analyze data with bioinformatic pipelines, and maintain electronic lab notebooks.

Qualifications

• Bachelor’s or Master’s in Chemical Biology, Biological Sciences or related field.
• 1–3 years of scientific experience.
• Self-motivated with ability to work both collaboratively and independently.

Responsibilities

• Design and execute discovery proteomic screens using mass spectrometry.
• Perform proximity biotinylation studies in cells with established workflows.
• Generate protein conjugates and characterize protein labeling.
• Analyze data using established bioinformatic pipelines.

Skills

Proteomics

Mass spectrometry

Bioinformatics

Mammalian cell culture

Education

Bachelor’s or Master’s in Chemical Biology/Biological Sciences or related field

Tools

Mass spectrometry workflows

DIA mass spectrometry

Job description

• We are seeking a highly motivated and talented scientist to join Clients Chemical Biology and Proteomics group within Discovery Sciences.
• As a contract Associate Scientist you will apply proteomics to advance drug discovery, with a fixed term of 12-months with potential opportunity for extension.
• You will have the opportunity to work with a team of cross-functional scientists and support the development of new and successful therapies for patients.
• If you're inspired by the possibilities of science to make a difference and ready to discover what you can do - join us.

Chemical Biology (Cambridge, MA)

• The Discovery Sciences department develops and applies the latest technologies for target discovery, hit identification and lead optimisation across Client's key therapy areas.
• The contract Associate Scientist will work in the Chemical Biology and Proteomics group to leverage chemical tools and proteomics technologies to conduct cellular profiling and mechanistic studies to better understand protein targets and therapeutic agents and enable project progression towards the clinic.

Major Responsibilities

• Design and execute discovery proteomic screens using mass spectrometry to support mechanistic studies, discover novel targets, and elucidate novel disease biology.
• Perform proximity biotinylation studies in cells, using established automated affinity purification workflows, and data independent acquisition (DIA) mass spectrometry methods.
• Generate protein conjugates and characterize protein labeling.
• Analyze and interpret experimental data using established bioinformatic pipelines.
• Maintain detailed and accurate electronic laboratory notebooks.
• Generate and communicate cohesive scientific reports and participate in meetings within a cross-functional team.

Requirements

• Bachelor's or Master's in Chemical Biology, Biological Sciences or related field, with 1 - 3 years of scientific experience.
• Candidate must be self-motivated with a desire to learn, and an ability to effectively work both collaboratively and independently.

Preferred Background

• Exposure to mammalian cell culture.
• Experience interpreting and/or generating scientific figures.
• Hands-on experience processing proteomics samples is a plus.