Scientist, Proteomics

inotivco; Nashville (TN); On-site; USD 70,000 - 90,000; Full time

Job summary

Inotiv in Nashville is seeking an early‑career Scientist I, Proteomics to conduct targeted and global proteomic bioanalytical studies supporting drug discovery and translational research. You will perform sample preparation, LC-MS/MS analysis, and data processing under supervision, contributing to the development of proteomic assays.

The role involves multiple cross-functional collaborations, staying current with literature, and adhering to GLP/SOP requirements while growing technical expertise

Qualifications

• Master's degree or PhD in Chemistry, Biochemistry, or a related field, with hands-on mass spectrometry proteomics experience.
• 2–3 years of relevant industry experience (CRO, biotech, pharma) or postdoc.
• Hands-on experience with targeted and/or global proteomic workflows and operation of high-resolution LC-MS/MS systems.

Responsibilities

• Contributes proteomics expertise to cross-functional DTS teams including biomarker discovery and translational research.
• Supports evaluation and implementation of new MS-based technologies and workflows.
• Communicates results to Study Directors and Sponsors and contributes to posters, publications, and presentations.
• Performs method development and validation and sample-preparation workflows; maintains LC-MS/MS instrumentation.
• Builds knowledge of Inotiv's capabilities at the Nashville site and performs data QC and report preparation.
• Shares technical knowledge and may train team members; adheres to GLP and SOPs.

Skills

Mass spectrometry

Proteomics

LC-MS/MS

Data analysis

Bioanalysis

SOPs

Communication

GLP

Team collaboration

Education

Master's degree in Chemistry/Biochemistry

PhD in related field

Tools

Skyline

FragPipe

Proteome Discoverer

Job description

Proteomics has emerged as a critical discipline driving contemporary drug discovery and clinical pharmacology. Once reserved as a support function to biochemistry organizations, proteomics is now an integral part of the drug discovery engine, working as a concerted discipline-team alongside pharmacology and molecular pathology within the Discovery & Translational Sciences (DTS) Division of Inotiv. We're looking for an early-career scientist who is excited by that mission and wants to grow their expertise where proteomic data makes a real difference.

The Scientist I, Proteomics is a Master's- or PhD-level scientist who conducts targeted and global proteomic bioanalytical studies supporting drug discovery, biomarker, and translational research programs. Working under the guidance of senior proteomics staff, this role performs hands-on sample preparation, LC-MS/MS analysis, and data processing, contributes to the development and qualification of proteomic assays, and supports communication of results to Study Directors and Sponsors. This is an excellent opportunity for an early-career scientist to grow their technical and scientific expertise within a collaborative, cross-functional drug discovery environment.

Scientific Responsibilities

• Contributes proteomics expertise to cross-functional project teams within DTS, collaborating with In Vivo Pharmacology, Molecular/Cellular Pharmacology, and Investigative & Molecular Pathology to support biomarker discovery, target validation, and translational research programs.
• Supports the evaluation and implementation of new mass spectrometry-based technologies and workflows, including biomarker-based expression profiling efforts in partnership with Molecular Pathology.
• Supports communication with Study Directors and Sponsors on targeted and global proteomics bioanalytical projects, and contributes to scientific posters, publications, and presentations that showcase Inotiv's proteomics capabilities.
• Performs, and contributes to the design of, targeted and global/discovery proteomics studies under the direction of senior scientists, ensuring compliance with established best practices and SOPs.
• Executes and assists with method development and validation (GxP and non-GxP) and sample-preparation workflows (protein digestion, immunoaffinity enrichment, high-abundance protein depletion, phospho-proteomics); operates and performs routine maintenance on LC-MS/MS instrumentation, chromatography, and automation systems.
• Performs bioinformatic and statistical analysis of proteomic datasets (e.g., Skyline, FragPipe, Proteome Discoverer) to identify, quantify, and interpret protein and peptide biomarkers, and presents findings to the project team.
• Drafts and revises SOPs for proteomic sample preparation, LC-MS/MS methods, and data analysis; stays current with scientific literature and emerging technologies.
• Builds working knowledge of Inotiv's capabilities, particularly at the Nashville site; performs quality control checks of data, prepares data summaries and report sections, and troubleshoots method and assay issues, escalating to senior staff as appropriate.
• Shares technical knowledge with colleagues and may assist in training team members on established proteomic and mass spectrometry techniques.
• Follows GLP and SOP requirements, including timely reporting of deviations, accurate documentation, and archival of study data and samples.
• Works with study management and operations teams to keep projects on track and support customer satisfaction from initiation through completion.
• Upholds Inotiv Core Values, safety regulations, and confidentiality standards, and interacts professionally with clients, colleagues, and the community.

Teamwork & Professional Development

• Works collaboratively within the proteomics team and with cross-functional partners to meet project timelines and deliverables.
• Takes ownership of professional development, seeking out training and mentorship to deepen expertise in proteomics, mass spectrometry, and regulated bioanalysis.
• Participates actively in team meetings, scientific discussions, and continuous-improvement initiatives.
• Contributes to an environment that supports the company's commitment to equal employment opportunities and the value of a diverse workforce.

Minimum Requirements

• Master's degree or PhD in Chemistry, Biochemistry, or a related field, with hands-on experience in mass spectrometry-based proteomics.
• 2-3 years of relevant industry experience (e.g., CRO, biotech, or pharmaceutical) or postdoctoral training in proteomics or a related field preferred.
• Hands-on experience with targeted and/or global/discovery proteomic workflows, including operation of high-resolution LC-MS/MS instrumentation for peptide and protein analysis.
• Working knowledge of protein/peptide separation, digestion, and enrichment techniques (e.g., immunoaffinity capture, fractionation, high-abundance protein depletion) and chromatographic systems used for pr