Scientist 3, Functional Immunogenomics

Genentech; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech is seeking a Scientist 3 within the CTG to advance target discovery through state-of-the-art genomics, functional readouts, and molecular engineering in immune-mediated diseases.

The role combines technology development with disease biology, requiring collaboration across immunology, genomics, and computational biology. A strong publication and/or patent record is valued, and relocation benefits are available.

Qualifications

• PhD in molecular biology, genetics, immunology, or related field.
• Experience with immunology and primary immune cell culture; in vivo experience is a plus.
• Experience deploying molecular engineering tools at scale in primary immune cells or iPSCs.

Responsibilities

• Develop and deploy molecular engineering technologies and read-outs.
• Interrogate immunological disease mechanisms at scale to identify targets and cell therapy strategies.
• Collaborate with multidisciplinary teams across immunology, genomics, computational biology, and AI/ML.

Skills

Immunology expertise

Molecular engineering

Leadership

Scientific productivity

Problem solving

Communication skills

Computational analyses

Single-cell genomics

Education

PhD in a relevant field

Tools

CRISPR (CRISPRko, CRISPRi/a)

Deep mutational scanning

Lineage tracing

Molecular recorders

NGS / genomics tools

Job description

The Position

The Opportunity

The Department of Cell and Tissue Genomics (CTG) at Genentech is seeking a highly motivated and innovative Scientist 3 to leverage cutting-edge genomics strategies for target discovery and next-generation therapeutic engineering. In this role, you will develop and deploy molecular engineering technologies, biologically relevant models, and state-of-the-art genomics, functional, and imaging read-outs to interrogate complex immunological disease mechanisms at scale. By integrating complex experimental systems with deep biological insights, you will directly drive the identification of novel molecular mechanisms, target candidates, and cell therapy strategies for immune-mediated diseases.

The ideal candidate thrives at the interface of technology development and disease biology—building and applying cutting-edge molecular tools to extract actionable biological insights. The candidate will work collaboratively with scientists of diverse expertise, including immunology, cell therapy, genomics, human genetics, computational biology, and AI/ML. No prior industry experience required, but an open and curious scientific mind is essential, as well as strong communication skills. If you are passionate about pushing the boundaries of functional genomics to transform how we understand and treat complex immune-mediated diseases, we encourage you to apply.

Who You Are

• Education: Doctorate degree in a relevant field, including molecular biology, genetics, immunology, systems biology, synthetic biology, developmental biology, biochemistry, and/or biomedical engineering.
• Immunology: Deep expertise in immunology, including primary immune cell culture and functional assays. In vivo experience a plus
• Molecular Engineering: Strong foundational background in molecular biology and functional genomics tools, such as CRISPR (CRISPRko, CRISPRi/a, base editing), deep mutational scanning, lineage tracing, molecular recorders. Experience deploying these at scale and in primary immune cells and/or iPSCs is a plus.
• High-content genomics: Experience in NGS, single-cell genomics, proteomics and/or imaging
• Leadership: Ability to manage multiple projects in parallel, collaborate effectively with multidisciplinary teams, and lead research projects.
• Scientific Productivity: Sustained record of productivity in the form of publications and/or patents.
• Proficiency in a broad range of biochemical, molecular, and cell biology techniques including flow cytometry.
• Excellent problem-solving skills and the ability to independently design, execute, and interpret experiments.
• Strong communication skills and a genuine enthusiasm for collaborative, team-based science.
• Motivation to learn new experimental approaches and computational analyses, and the curiosity to explore unconventional ideas.

Preferred:

• Data Analysis: Experience in the analysis of single cell and genomic data using R and/or Python.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.