Scientist 3 – Translational Medicine, Oncology

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 121,000 - 224,000; Full time

Benefits offered by this job

Annual bonus

Job summary

Genentech seeks a Scientist 3 in Translational Medicine, Oncology to lead hands-on lab research in lung and GI cancers. You will design experiments, analyze complex data, and collaborate with Oncology, Computational Sciences, and Translational Genomics teams to advance biomarkers and therapies.

The role emphasizes strong experimental design, data interpretation, and adoption of emerging translational technologies such as single-cell and spatial profiling to inform patient selection and biomarker

Qualifications

• Ph.D. in Cancer Biology, Cell Biology, Immunology, or related fields (or BA/BS/MS with 6+ years).
• Deep cancer biology and immunology knowledge; lung/GI cancer context is a plus.
• Experience leading hands-on lab-based translational research and developing assays.

Responsibilities

• Design and execute experiments to validate hypotheses from non-clinical and clinical data.
• Analyze and interpret experimental and computational results with cross-functional teams.
• Elucidate action mechanisms and resistance to immunotherapies/targeted therapies.
• Develop and apply multi-omic and cell-based assays for translational questions.
• Establish collaborations to access new technologies and datasets.

Skills

Lab leadership

Multi-omics assays

Flow cytometry

Cell culture

Experimental design

Collaborative work

Education

Ph.D. in Cancer Biology

BA/BS or MS + 6+ years experience

Tools

Single-cell analysis

Spatial transcriptomics

In vivo models

High-dimensional data analysis

Biomarker assays

Job description

Scientist 3 – Translational Medicine, Oncology

We advance science so that we all have more time with the people we love.

The Translational Medicine organization at Genentech has a vision to transform patient care through borderless, innovative, and rigorous translational science that will catalyze the development of new medicines, accelerate drug development timelines, and discover new therapeutic strategies. To fulfill our vision, we recruit talented and highly motivated scientists to develop and execute innovative biomarker and diagnostic strategies to drive clinical development through all phases of the portfolio, and conduct foundational disease-oriented translational research to maximize our scientific and clinical impact.

We are seeking a dedicated and independent Scientist 3 to lead lab-based translational research and discovery efforts in lung and gastrointestinal (GI) cancers.

Key Responsibilities:

This is a hands-on, laboratory-based position that offers the chance to collaborate closely with teams across Genentech Research & Early Development (gRED) - including Research Oncology, Computational Sciences, and Translational Genomics and Proteomics. As an integral member of this cross-functional team, you will:

• Design and execute experiments to validate biological and therapeutic hypotheses derived from non-clinical, clinical, and real‑world data
• Synthesize, analyze, and interpret experimental and computational data in collaboration with experts from other functions
• Elucidate mechanisms of action and therapeutic resistance to tumor microenvironment and tumor targeted therapies (eg next-generation checkpoint inhibitors and antibody drug conjugates) to guide patient selection, pharmacodynamic biomarker assessment, combination treatment strategies, and next-generation target identification
• Identify, evaluate, and validate innovative cell-based, biochemical, and multi‑omic assays-including single-cell and functional genomics technologies- to enable scalable hypothesis testing
• Proactively establish new internal and external collaborations to access emerging technologies, datasets, and analytical methods that fuel translational innovation

Qualifications

• Education: Ph.D. degree in Cancer Biology, Cell Biology, Immunology, or related disciplines. Candidates with a BA/BS or MS degree in similar fields, with combined 6+ or 4+ additional years of related experiences, respectively, will also be considered
• Scientific expertise: deep understanding of cancer biology, cancer immunology, and mechanisms of action and resistance to immunotherapies and/or targeted therapies. An understanding of lung and GI cancer disease biology, tumor-immune interactions, and key oncogenic signaling pathways would be advantageous.
• Technical proficiency: proven ability to independently lead hands‑on, lab‑based research and to develop, optimize, and apply fit‑for‑purpose experimental assays using relevant preclinical models and human samples. Multidisciplinary expertise in complementary approaches such as primary immune and/or tumor cell isolation and culture, immune‑cell functional and tumor‑killing assays, target‑engagement and pharmacodynamic biomarker assays, multiparameter flow cytometry, and 2D/3D tumor microenvironment models, including ex vivo and in vivo approaches where appropriate. Strong interest in and experience applying emerging translational technologies—such as single‑cell and multi‑omic profiling, spatial approaches, advanced functional assays, and other novel platforms—to address mechanistic and biomarker questions is highly desirable.
• Possess a rigorous and creative approach to experimental design and problem‑solving. Highly organized, detail‑oriented and adaptable in a fast‑paced, collaborative environment. Excellent written and verbal communication skills.

Preferred Qualification:

Proficient with analysis of high‑throughput data, such as multiomics, single cell and spatial transcriptomics datasets

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $120,700-$224,100 . Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.