Scientist 3, Cell Therapy T cell Differentiation

Genentech; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech's Cell Therapy team in South San Francisco seeks a Scientist 3 to advance iPSC-to-T cell differentiation platforms and drive high-quality cell products for therapeutic programs.

You will develop and optimize differentiation protocols, study lineage specification and maturation, and translate findings into improvements in yield, phenotype, and function while collaborating across gRED and with external partners. Relocation benefits available.

Qualifications

• PhD in Immunology, Stem Cell Biology, or related field with at least 3 years of relevant experience.
• Hands-on experience differentiating iPSCs to T cells and/or immune lineages.
• Strong cell and molecular biology background with mechanistic approaches.
• Experience evaluating and optimizing stem cell differentiation platforms.
• Experience with phenotypic and functional assays for T cells.
• Excellent organizational and communication skills for cross-functional work.

Responsibilities

• Develop, optimize, and implement iPSC-to-T cell differentiation protocols across programs.
• Investigate cellular/molecular mechanisms of T-cell lineage specification and maturation.
• Translate findings into improvements in cell-product quality, yield, phenotype, and function.
• Analyze multidimensional datasets to guide experimental strategies.
• Collaborate with research, translational, computational, and external teams across gRED.
• Contribute to scientific and strategic planning for the Cell Therapy department.

Skills

iPSC-to-T cell differentiation

Cell & molecular biology

T cell functional assays

Data analysis

Scientific communication

Education

PhD in Immunology, Stem Cell Biology, or related field

Job description

The Position

Bold thinkers, breakthrough makers: Join a team of curious minds who challenge the status quo, create what’s next in science and technology, and have the freedom to turn daring ideas into real breakthroughs.

The Opportunity

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated, collaborative Scientist 3 to advance next-generation, off-the-shelf cell therapies for patients with intractable diseases. Reporting to a Principal Fellow, you will play a pivotal role in shaping our iPSC-to-T cell differentiation platform, directly influencing pipeline programs and mechanistic biology discoveries.

• Develop, optimize, and implement robust iPSC-to-T cell differentiation protocols in the context of diverse therapeutic programs.
• Investigate cellular and molecular mechanisms underlying T-cell lineage specification, differentiation efficiency, and maturation to drive process enhancements.
• Translate biological discoveries into tangible improvements in cell-product quality, yield, phenotype, and function.
• Analyze complex, multidimensional datasets to draw incisive conclusions and guide subsequent experimental strategies.
• Collaborate cross-functionally with research, translational, computational, process development, and external partner groups across gRED.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader therapeutic pipeline.

Who you are

• PhD in Immunology, Stem Cell Biology, Cell & Molecular Biology, or related field with at least 3 years of relevant experience.
• Extensive hands-on experience differentiating iPSCs to T cell and/or other immune cell lineages.
• Strong cell and molecular biology background with a demonstrated ability to apply mechanistic approaches to investigate cell fate decisions.
• Proven track record of evaluating and optimizing the robustness, consistency, and reproducibility of stem cell differentiation platforms.
• Deep experience developing and applying phenotypic and functional assays to characterize T cell activity, fitness, and potency.
• Strong organizational, written, and verbal communication skills with a demonstrated history of collaborative delivery across multidisciplinary teams.

Preferred

• Experience with Design of Experiments (DOE), high-throughput screening, or other quantitative multivariate process-optimization methodologies.
• Prior experience in cell therapy or drug development, understanding critical quality attributes (identity, purity, yield, viability, and potency).
• Hands-on expertise with CRISPR/Cas9 or other genome-engineering modalities in stem cells (iPSCs).
• Demonstrated record of scientific impact through high-impact publications, patents, or contributions to therapeutic advancement.

Location

• This is a lab-based role at our South San Francisco, CA campus. Onsite presence is required.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of CA is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.