Scientist 3 - Translational Medicine, Oncology

Genentech; South San Francisco (CA); Sur place; USD 121 000 - 224 000; Plein temps

Avantages offerts par ce poste

Discretionary annual bonus

Benefits package

Résumé du poste

Genentech is seeking a Scientist 3 in Translational Medicine (Oncology) based in California. You will design and execute experiments to validate hypotheses from non-clinical to real-world data and lead biomarker-driven strategies to accelerate clinical development.

You will collaborate across teams to elucidate mechanisms of action, develop fit-for-purpose assays, and apply multi-omic approaches to address biomarker questions. A Ph.D. and strong communication skills are required.

Qualifications

• Ph.D. in Cancer Biology, Cell Biology, Immunology or related disciplines; BA/BS/MS with related experience considered.
• Deep understanding of cancer biology, cancer immunology and immunotherapy mechanisms.
• Proven ability to lead hands-on lab-based research and to develop relevant assays.

Responsabilités

• Design and execute experiments to validate biological and therapeutic hypotheses derived from non-clinical, clinical, and real-world data.
• Synthesize, analyze, and interpret experimental and computational data in collaboration with other functions.
• Elucidate mechanisms of action and resistance to guide patient selection and biomarker assessment.
• Identify and validate cell-based, biochemical, and multi-omic assays for scalable testing.
• Establish collaborations to access emerging technologies and datasets for translational innovation.

Connaissances

Cancer biology

Immunology

Immunotherapies / targeted therapies

Single-cell & multi-omics profiling

Lab-based research leadership

Formation

Ph.D. in Cancer Biology, Cell Biology, Immunology

BA/BS or MS with 6+ years related experience

Outils

Flow cytometry

Preclinical models

Spatial transcriptomics

Single-cell & multi-omics platforms

Description du poste

Scientist 3 - Translational Medicine, Oncology

We advance science so that we all have more time with the people we love.

The Translational Medicine organization at Genentech has a vision to transform patient care through borderless, innovative, and rigorous translational science that will catalyze the development of new medicines, accelerate drug development timelines, and discover new therapeutic strategies. To fulfill our vision, we recruit talented and highly motivated scientists to develop and execute innovative biomarker and diagnostic strategies to drive clinical development through all phases of the portfolio, and conduct foundational disease-oriented translational research to maximize our scientific and clinical impact.

Key Responsibilities:

• Design and execute experiments to validate biological and therapeutic hypotheses derived from non-clinical, clinical, and real-world data
• Synthesize, analyze, and interpret experimental and computational data in collaboration with experts from other functions
• Elucidate mechanisms of action and therapeutic resistance to tumor microenvironment and tumor targeted therapies (eg next-generation checkpoint inhibitors and antibody drug conjugates) to guide patient selection, pharmacodynamic biomarker assessment, combination treatment strategies, and next-generation target identification
• Identify, evaluate, and validate innovative cell-based, biochemical, and multi-omic assays-including single-cell and functional genomics technologies- to enable scalable hypothesis testing
• Proactively establish new internal and external collaborations to access emerging technologies, datasets, and analytical methods that fuel translational innovation

Qualifications

• Education: Ph.D. degree in Cancer Biology, Cell Biology, Immunology, or related disciplines. Candidates with a BA/BS or MS degree in similar fields, with combined 6+ or 4+ additional years of related experiences, respectively, will also be considered
• Scientific expertise: deep understanding of cancer biology, cancer immunology, and mechanisms of action and resistance to immunotherapies and/or targeted therapies. An understanding of lung and GI cancer disease biology, tumor-immune interactions, and key oncogenic signaling pathways would be advantageous
• Technical proficiency: proven ability to independently lead hands-on, lab-based research and to develop, optimize, and apply fit-for-purpose experimental assays using relevant preclinical models and human samples. Multidisciplinary expertise in complementary approaches such as primary immune and/or tumor cell isolation and culture, immune-cell functional and tumor-killing assays, target-engagement and pharmacodynamic biomarker assays, multiparameter flow cytometry, and 2D/3D tumor microenvironment models, including ex vivo and in vivo approaches where appropriate. Strong interest in and experience applying emerging translational technologies-such as single-cell and multi-omic profiling, spatial approaches, advanced functional assays, and other novel platforms-to address mechanistic and biomarker questions is highly desirable
• Possess a rigorous and creative approach to experimental design and problem-solving. Highly organized, detail-oriented and adaptable in a fast-paced, collaborative environment. Excellent written and verbal communication skills

Preferred Qualification

• Proficient with analysis of high-throughput data, such as multiomics, single cell and spatial transcriptomics datasets

Relocation benefits are not available for this posting.

The expected salary range for this position based on the primary location of California is $120,700-$224,100 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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