Scientist 3, Single Cell & Functional Genomics

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 103,400 - 192,000; Full time

Benefits offered by this job

Relocation benefits

Job summary

Genentech in California is seeking a Scientist 3 to execute cutting-edge single-cell and functional genomic techniques to study cancer biology. This hands-on role combines experiments with computational analysis and high-throughput screens to profile cancer models and interrogate molecular mechanisms underlying disease states.

You will deploy new and existing single-cell profiling methods, analyze genomic data, collaborate across departments, and contribute to identifying therapeutic targets.

Qualifications

• Doctorate degree in a relevant field (molecular/cancer biology, genetics, immunology, systems biology, biochemistry or biomedical engineering).
• Hands-on experience performing and analyzing single cell CRISPR screens.
• Experience in analysis of single cell and genomic data using R and/or Python.
• Strong foundational background in NGS assays and molecular biology techniques.
• Excellent oral and written presentation skills.
• Ability to manage multiple projects in parallel and lead research efforts.
• Preferred: epigenomics experience and cancer biology disease expertise.

Responsibilities

• Perform high-throughput screens in cancer cell lines and models.
• Develop and apply single cell technologies to profile primary tissue samples.
• Analyze and interpret single cell perturbation data and broader genomic data.
• Collaborate with teams within the department and across the wider organization.
• Communicate results clearly through high-impact scientific publications and presentations.
• Contribute to identifying new research opportunities and innovative technology applications.

Education

Doctorate degree in a relevant field

Tools

R

Python

NGS workflows

Job description

Overview

The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to execute cutting-edge single-cell and functional genomic techniques to study cancer biology. The successful candidate will perform high-throughput screens, deploy new and existing single cell profiling methods, and analyze genomic data to enable the interrogation of molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. This is a hands-on position with both experimental and computational analysis components in collaboration with colleagues across departments.

Responsibilities

• Perform high-throughput screens in cancer cell lines and models.
• Develop and apply single cell technologies to profile primary tissue samples.
• Analyze and interpret single cell perturbation data and broader genomic data.
• Collaborate with teams within the department and across the wider organization.
• Communicate results clearly through high-impact scientific publications and presentations.
• Contribute to identifying new research opportunities and innovative technology applications.

Qualifications

• Education: Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering.
• Screening Experience: Hands-on experience performing and analyzing single cell CRISPR screens.
• Data Analysis: Experience in the analysis of single cell and genomic data using R and/or Python.
• NGS Assay Expertise: Strong foundational background in NGS assays and molecular biology techniques.
• Professional Skills: Excellent oral and written presentation skills.
• Leadership: Ability to manage multiple projects in parallel, collaborate effectively with multidisciplinary teams, and lead research projects.
• Scientific Productivity: Sustained record of productivity in the form of publications and patents.
• Preferred: Epigenomics experience and cancer biology disease expertise.

Compensation and Benefits

Relocation benefits are available. Salary range for this position, based on the primary location of California, is $103,400 to $192,000. Actual pay is determined by experience, qualifications, geographic location, and other factors permitted by law. A discretionary annual bonus may be available based on individual and company performance.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence, in compliance with all applicable laws. If you require an accommodation in relation to the online application process, please contact Accommodations for Applicants.