Scientist 3, Cell Therapy T cell Differentiation

F. Hoffmann-La Roche AG; South San Francisco (CA); On-site; USD 103,000 - 192,000; Full time

Job summary

Genentech, a Roche subsidiary, is seeking a Scientist 3 in the Cell Therapy department to advance iPSC-to-T cell differentiation platforms for next-generation therapies at the South San Francisco campus. This lab-based role emphasizes mechanistic biology, optimization of differentiation protocols, and collaboration across multidisciplinary teams to drive pipeline programs and improve product quality.

You will investigate lineage specification, maturation, and functional assays to characterize T

Qualifications

• PhD in immunology, stem cell biology, or related field with ≥3 years of relevant experience.
• Hands-on experience differentiating iPSCs to T cells or other immune lineages.
• Strong cell and molecular biology background with mechanistic approaches.
• Experience evaluating the robustness and reproducibility of stem cell differentiation platforms.
• Experience developing phenotypic and functional assays to characterize T cell activity, fitness, and potency.
• Excellent written and verbal communication; collaboration across multidisciplinary teams.

Responsibilities

• Develop, optimize, and implement iPSC-to-T cell differentiation protocols for diverse programs.
• Investigate mechanisms of T-cell lineage specification and differentiation to improve yield and function.
• Translate discoveries into improvements in cell-product quality and potency.
• Analyze complex datasets to guide experimental strategy and decision making.
• Collaborate across r&d, translational, computational, process development, and external partners.

Skills

iPSC to T cell differentiation

Cell biology

Molecular biology

Mechanistic assays

T cell assays

Functional assays

Communication

DOE

High-throughput screening

CRISPR/Cas9

Genome editing in stem cells

Cell therapy

Publications/Patents

Education

PhD in Immunology, Stem Cell Biology, or related field

Job description

The Opportunity

Bold thinkers, breakthrough makers: Join a team of curious minds who challenge the status quo, create what’s next in science and technology, and have the freedom to turn daring ideas into real breakthroughs.

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated, collaborative Scientist 3 to advance next-generation, off-the-shelf cell therapies for patients with intractable diseases. Reporting to a Principal Fellow, you will play a pivotal role in shaping our iPSC-to-T cell differentiation platform, directly influencing pipeline programs and mechanistic biology discoveries.

Develop, optimize, and implement robust iPSC-to-T cell differentiation protocols in the context of diverse therapeutic programs. Investigate cellular and molecular mechanisms underlying T-cell lineage specification, differentiation efficiency, and maturation to drive process enhancements. Translate biological discoveries into tangible improvements in cell-product quality, yield, phenotype, and function. Analyze complex, multidimensional datasets to draw incisive conclusions and guide subsequent experimental strategies. Collaborate cross-functionally with research, translational, computational, process development, and external partner groups across gRED. Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader therapeutic pipeline.

Who you are

• PhD in Immunology, Stem Cell Biology, Cell & Molecular Biology, or related field with at least 3 years of relevant experience.


• Extensive hands-on experience differentiating iPSCs to T cell and/or other immune cell lineages.


• Strong cell and molecular biology background with a demonstrated ability to apply mechanistic approaches to investigate cell fate decisions.


• Proven track record of evaluating and optimizing the robustness, consistency, and reproducibility of stem cell differentiation platforms.


• Deep experience developing and applying phenotypic and functional assays to characterize T cell activity, fitness, and potency.


• Strong organizational, written, and verbal communication skills with a demonstrated history of collaborative delivery across multidisciplinary teams.

Preferred Experience

• Experience with Design of Experiments (DOE), high-throughput screening, or other quantitative multivariate process-optimization methodologies.


• Prior experience in cell therapy or drug development, understanding critical quality attributes (identity, purity, yield, viability, and potency).


• Hands-on expertise with CRISPR/Cas9 or other genome-engineering modalities in stem cells (iPSCs).


• Demonstrated record of scientific impact through high-impact publications, patents, or contributions to therapeutic advancement.

Location

This is a lab-based role at our South San Francisco, CA campus. Onsite presence is required. Relocation benefits are available for this job posting.

Salary and Benefits

The expected salary range for this position based on the primary location of CA is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.