Scientist

Amgen; Thousand Oaks (CA); On-site; USD 120,000 - 210,000; Full time

Job summary

Amgen seeks a mass spectrometry scientist and analytical protein chemist with a proven track record in supporting biopharmaceutical proteins, scientific eminence, leadership, and mentoring skills. You will join the BEAM group, offering scientific and technical expertise to support discovery through to late-stage optimization of Amgen’s drug candidates.

You will apply LC-MS for intact protein and subunit analyses, work with high-throughput MS, perform protein digestion and PTM mapping, and handle

Qualifications

• Doctorate or equivalent in analytical chemistry or biochemistry.
• Experience with LC-MS for intact protein and subunits.
• Experience with high-throughput MS (Rapidfire) is a plus.
• Ability to communicate scientific concepts clearly.

Responsibilities

• Provide scientific and technical expertise from early discovery to late-stage optimization.
• Design, execute and interpret MS-based analyses.
• Maintain accurate records in an electronic lab notebook.
• Mentor and lead projects to required deadlines.

Skills

RPLC-MS

MS analytics

Protein digestion

MS/MS

Data processing

Communication

Independent work

Electronic lab notebook

Education

Doctorate degree

Master’s degree + 2 years biopharmaceutical Analytical Chemistry

Bachelor’s degree + 4 years biopharmaceutical Analytical Chemistry

Tools

MassHunter

XCalibur

MassLynx

ChemStation

Chromeleon

GeneData Expressionist

Excel

Spotfire

JMP

Job description

Let’s do this. Let’s change the world. We are seeking a mass spectrometry scientist and analytical protein chemist with a consistent track record in biopharmaceutical protein support, scientific eminence and leadership and mentoring skills.

In this vital role you will be part of the BEAM group providing scientific and technical expertise to support early discovery research through to later stage molecule optimization and late-stage selection of Amgen’s pipeline of drug candidates. This position is an exciting opportunity to unlock the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing, and delivering innovative human therapeutics.

• Experience using analytical characterization techniques such as RPLC-MS for intact protein, reduced and subunit protein mass analysis. Experience using high-throughput MS like Rapidfire-MS is a plus.
• Experience with protein digestion and RPLC-MS/MS to map protein sequence and characterize post translational modifications such as deamidation, isomerization and oxidation and associated data processing would be a plus.
• Experience generating, processing and using large LC-MS analytical data sets
• Experience with both ESI and MALDI techniques would be useful
• Communicate (verbal and in written) scientific concepts and results
• Work independently in advancing projects and studies within required deadlines
• Follow protocols and procedures, maintain accurate records in an electronic lab notebook

the contract can be extended yearly.

Basic Qualifications:

Doctorate degree

Or

Master’s degree and 2 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent

Or

Bachelor’s degree and 4 years of biopharmaceutical Analytical Chemistry, Biochemistry or equivalent

Preferred Qualifications

• Master or PhD level qualification with an emphasis in mass spectrometric analytical characterization.
• Knowledge of multiple mass spectrometric (MassHunter, XCalibur, MassLynx) chromatographic (ChemStation, Chromeleon) control software is preferred. Knowledge of GeneData Expressionist data processing software is a plus.
• Knowledge of statistical processing of data, including related software such as, but not limited to Excel, Spotfire or JMP is preferred