Senior Scientist

Johnson & Johnson Innovative Medicine; Malvern (Chester County); On-site; USD 120,000 - 150,000; Full time

Job summary

Johnson & Johnson Innovative Medicine in Malvern, PA is seeking a Senior Scientist for Protein Analytical Development, Characterization. You will lead development, design and execution of mass spectrometry assays to support product characterization and process development of protein-based therapeutics.

The role reports to the Scientific Director and collaborates with cross-functional teams to advance analytical technologies for clinical development and commercialization.

Qualifications

• Minimum of 4 years’ experience after a Master’s degree or 0–2 years after a PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field.
• Hands-on Mass Spectrometry experience including intact mass analysis and peptide mapping.

Responsibilities

• Develop, design and perform mass spectrometry assays for protein characterization and process development.
• Drive innovation by evaluating and implementing emerging analytical technologies.
• Serve as a key technical contributor on cross-functional teams, guiding discussions and analyses.
• Maintain GMP-compliant documentation and generate protocols and regulatory-supporting reports.

Skills

Mass spectrometry

Education

Master's degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field

PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field

Tools

Protein Matrix

Genedata Expressionist

Job description

We are searching for the best talent for a Senior Scientist, Protein Analytical Development, Characterization located in Malvern, PA.

Purpose:
The Therapeutics Development and Supply, Protein Development, Analytical Development organization is recruiting a highly skilled and motivated Senior Scientist to join our Protein Analytical Development Characterization group. The role reports to the Scientific Director within the Characterization group and will lead development, design and execution of mass spectrometry assays in support of product characterization and process development of protein-based therapeutics. The successful candidate will play a key role in advancing innovative analytical technologies and delivering phase-appropriate characterization across clinical development and commercialization to ensure the successful advancement of our therapeutic portfolio.

You will be responsible for:

• Develop, design and perform mass spectrometry assays in support of product characterization and process development activities for protein and protein conjugates.


• Drive innovation by evaluating and implementing emerging analytical technologies to enhance characterization strategies.


• Serve as a key technical contributor on cross-functional project teams, leading scientific discussions and providing analytical expertise to support project objectives.


• Maintain accurate laboratory documentation and author protocols, technical reports, and regulatory-supporting documents in compliance with Good Manufacturing Practice (GMP) requirements.

Required:

• Minimum of 4 years’ experience following the completion of a Master’s degree or 0-2 years’ experience following the completion of a PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field is required.


• Hands-on experience with Mass Spectrometry (intact mass analysis, peptide mapping, etc.)


• Experience working with protein/antibody
  

Preferred:

• Experience with 3rd party MS software (e.g., Protein Matrix, Genedata Expressionist, etc.)


• Experience working with antibody drug conjugate


• Experience working in a GLP/GMP environment


• Experience and understanding of pharmaceutical development CMC and regulatory requirements for protein biologics