RNA Synthesis & Process Development Scientist

Bristol Myers Squibb; Cambridge (MA); On-site; USD 96,000 - 116,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA seeks a Senior Associate Scientist to advance RNA synthesis processes from research concepts to manufacturing-ready methods. You will collaborate across research and manufacturing to define early process conditions and drive scalable development for RNA modalities.

The role emphasizes hands-on experimentation, cross-functional teamwork, and preparing technical reports while supporting tech transfer to GMP facilities.

Qualifications

• BS/MS in Bio/Chemical Engineering or Chemistry with relevant lab experience.
• 4+ years for BS or 2+ years for MS in science-related disciplines.
• Experience with automated liquid handlers and small-scale reactors.
• Familiarity with DoE and multivariate data analysis.
• Experience with HPLC, CE, and gel electrophoresis.
• Knowledge of cGMP/ICH and QbD principles.
• Experience supporting clinical manufacturing and process investigations.
• Ability to work cross-functionally and transfer to GMP manufacturing.

Responsibilities

• Apply high throughput and data driven approaches to perform early optimization and characterization of in vitro transcription, circularization and DNase reactions.
• Support the RNA drug substance synthesis process definition and scale up.
• Experiment using high throughput/automated or data rich experimental setups.
• Support experiments to confirm robust process performance across the control space.
• Collaborate with research teams to enable quicker transitions from drug candidate nomination to clinical manufacturing.
• Prepare sections of technical reports, and communicate findings internally as appropriate.
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs.

Skills

Automation skills

DoE & multivariate data

HPLC/CE/gel electrophoresis

LIMS/ELN & scripting

cGMP/ICH/QbD knowledge

Process development support

Mathematics & nucleic acid chemistry

Scale-down modelling

Education

Bio/Chemical Engineering

BS + 4+ years

MS + 2+ years

Job description

Bristol Myers Squibb in Cambridge, MA seeks a Senior Associate Scientist to advance RNA synthesis processes from research concepts to manufacturing-ready methods. You will collaborate across research and manufacturing to define early process conditions and drive scalable development for RNA modalities.

The role emphasizes hands-on experimentation, cross-functional teamwork, and preparing technical reports while supporting tech transfer to GMP facilities.