Senior Associate Scientist, RNA Analytics & LNPs

Bristol-Myers Squibb; Cambridge (MA); On-site; USD 94,000 - 114,000; Full time

Benefits offered by this job

Flexible Time Off

Comprehensive Benefits

Stock/Equity opportunities

Job summary

Bristol Myers Squibb in Cambridge, MA is seeking a Senior Associate Scientist with analytical method development expertise to advance RNA therapeutics. You will design and validate methods to characterize lipids, antibodies, and RNA modalities across discovery and development stages.

Responsibilities include method lifecycle activities, cross-functional collaboration, data interpretation, and reporting. Strong writing and regulatory familiarity are required.

Qualifications

• BS/MS in Analytical Chemistry, Biochemistry, or related field with 2+ years of CMC experience; PhD candidates considered.
• Hands-on experience with HPLC/UHPLC (IP-RP, RP, CAD) for RNA, lipid, and impurity quantitation.
• Experience with biophysical/biochemical characterization techniques and regulatory familiarity.

Responsibilities

• Independently design, develop, and optimize analytical methods for RNA therapeutics, lipid nanoparticles, and related components.
• Support routine and platform analytical testing for LNP-encapsulated RNA across safety, identity, content, purity, and potency.
• Lead method lifecycle activities: development, qualification, validation, transfer to CROs/CDMOs, with SOPs and reports.
• Collaborate cross-functionally to support analytical development and troubleshoot issues.
• Troubleshoot analytical challenges, interpret data, and propose improvements to assay performance.
• Perform and oversee routine and non-routine testing, data review, and regulatory-ready documentation.
• Operate, maintain, and troubleshoot analytical instrumentation.
• Communicate complex data through reports and presentations to inform decisions.

Skills

Analytical method development

RNA therapeutics

Lipid nanoparticles

HPLC/UHPLC

Biophysical characterization

Data analysis

Regulatory documentation

Education

BS/MS in Analytical Chemistry/Biochemistry

PhD candidate considered

Tools

DLS

RiboGreen

ELISA

Raman spectroscopy

UV-Vis spectrophotometry

Job description

Bristol Myers Squibb in Cambridge, MA is seeking a Senior Associate Scientist with analytical method development expertise to advance RNA therapeutics. You will design and validate methods to characterize lipids, antibodies, and RNA modalities across discovery and development stages.

Responsibilities include method lifecycle activities, cross-functional collaboration, data interpretation, and reporting. Strong writing and regulatory familiarity are required.