RNA Chemistry Associate Scientist - GMP for Prime Editing

Prime Medicine, Inc.; Cambridge (MA); On-site; USD 80,000 - 90,000; Full time

Job summary

Prime Medicine, Inc. in Cambridge, MA is seeking an Associate Scientist/Engineer II to join the RNA chemistry team within Technology, Development and Operations.

This hands‑on role supports process development, optimization and tech transfer of a manufacturing workflow for Prime Editing. You will work cross‑functionally with R&D, quality, and external partners, perform solid‑phase RNA synthesis and downstream purification, and author SOPs and batch records to advance GMP‑compliant manufacturing

Qualifications

• BS or MS in biotechnology, engineering, chemistry, biochemistry, or related life science with 1+ years (MS) or 3+ years (BS) of biotech/biopharma industry experience.
• Experience in chemistry process development of complex biomolecules; oligonucleotide synthesis or downstream purification is a plus.
• GMP manufacturing environment experience and ability to write SOPs/draft batch records.

Responsibilities

• Perform solid‑phase chemical synthesis of long guide RNA and downstream purification including chromatography, TFF and lyophilization at varying scales.
• Collaborate with team to incorporate findings into manufacturing process design.
• Manufacture IND‑enabling and GLP/GMP RNA guides to support Prime Editing programs.

Skills

GMP experience

Strong communication

Analytical skills

Education

BS or MS in biotechnology/engineering/chemistry/biochemistry

Tools

ÄKTA systèmes

AKTA purifiers

HPLC

TFF skids

Job description

Prime Medicine, Inc. in Cambridge, MA is seeking an Associate Scientist/Engineer II to join the RNA chemistry team within Technology, Development and Operations.

This hands‑on role supports process development, optimization and tech transfer of a manufacturing workflow for Prime Editing. You will work cross‑functionally with R&D, quality, and external partners, perform solid‑phase RNA synthesis and downstream purification, and author SOPs and batch records to advance GMP‑compliant manufacturing