Senior Oligonucleotide Scientist - RNA Synthesis & Analytics

Regeneron; Town of Mount Pleasant (NY); On-site; USD 80,000 - 131,000; Full time

Job summary

Regeneron Genetic Medicines in New York seeks a Senior Associate Scientist to join the RGM R&D Chemistry team, focusing on oligomer and oligonucleotide synthesis, purification, and analytical characterization. You will design solid‑phase workflows, prepare modified RNA‑related materials, and generate high‑quality data to guide platform development.

You’ll work at the interface of synthetic chemistry, analytical methods, and RNA therapeutics, collaborating with chemists, biologists, and project

Qualifications

• BS in chemistry, biochemistry, chemical biology, biology, or a related scientific discipline is required; Masters degree is preferred.
• Minimum of 5 years with BS / 3 years with MS in relevant undergraduate research, internship, or industry experience required.
• Hands-on experience with solid-phase organic synthesis is preferred, particularly oligonucleotide, peptide, oligomer, or related polymer/biopolymer synthesis workflows.
• Familiarity with automated synthesis platforms such as MerMade, OligoSynt, or comparable oligonucleotide/oligomer synthesizers is highly desirable. Experience with purification and analytical characterization methods, including SEC, AEX, RP-HPLC or RPIP-HPLC, and LC-MS.

Responsibilities

• Execute solid‑phase oligomer and oligonucleotide synthesis using automated synthesis platforms, including preparation of reagents, setup of synthesis cycles, incorporation of standard and chemically modified amidites, and on‑bead or post‑synthetic modifications as needed.
• Support synthesis of RNA‑related constructs of varied lengths, formats, and chemical modification to enable discovery, platform development, and cross‑functional program needs.
• Develop, optimize, and troubleshoot synthetic workflows to improve yield, purity, reproducibility, and process efficiency.
• Perform purification of synthesized oligomers using appropriate chromatographic techniques, including size‑exclusion, anion‑exchange, reverse‑phase, and ion‑pair reverse‑phase methods.
• Characterize purified materials using analytical methods such as LC‑MS, HPLC/UPLC, UV‑Vis, and other orthogonal techniques to confirm identity, purity, concentration, and product quality.
• Analyze and interpret experimental results, summarize findings clearly, and recommend next steps to support iterative chemistry design and platform advancement.
• Maintain accurate, complete, and timely experimental records in accordance with laboratory standards, safety expectations, and internal documentation practices.
• Collaborate effectively with chemists, biologists, analytical scientists, and project teams to advance RGM Chemistry objectives and communicate technical progress in team discussions.

Skills

Solid-phase synthesis

Oligonucleotide synthesis

Analytical characterization

LC-MS

HPLC/UPLC

Data analysis

Education

BS in chemistry/biochemistry

MS preferred

Tools

MerMade

OligoSynt

Job description

Regeneron Genetic Medicines in New York seeks a Senior Associate Scientist to join the RGM R&D Chemistry team, focusing on oligomer and oligonucleotide synthesis, purification, and analytical characterization. You will design solid‑phase workflows, prepare modified RNA‑related materials, and generate high‑quality data to guide platform development.

You’ll work at the interface of synthetic chemistry, analytical methods, and RNA therapeutics, collaborating with chemists, biologists, and project