Research Scientist

Beacon Hill Staffing Group, LLC; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Medical benefits

Paid time off

Job summary

Beacon Hill Staffing Group, LLC is seeking a highly skilled Scientist/Sr. Scientist to support discovery programs focused on targeted protein degradation and next‑generation biologics in Cambridge.

The role emphasizes mass spectrometry bioanalysis, protein/peptide characterization, and analytical assay development within a cross‑functional team. Candidates should have extensive hands‑on MS experience, strong methods development and validation background for large molecules, and excellent

Qualifications

• Minimum 5+ years of mass spectrometry bioanalytical experience.
• Experience with protein/peptide MS analysis (intact/subunit).
• Expertise in method development and validation for large molecules.
• Proficiency with RP-HPLC, SEC, HILIC, nanoLC, microLC.
• Strong data processing and cross‑functional communication.
• Hands‑on instrument maintenance and vendor coordination.
• Excellent organization and attention to detail.

Responsibilities

• Lead LC‑MS/MS assay development, validation and fit‑for‑purpose bioanalysis.
• Plan workflows for peptide mapping and PTM analysis.
• Develop bioanalytical methods for complex proteins.
• Set goals/timelines for bioanalysis in cross‑functional teams.
• Perform advanced data processing and statistical analysis.
• Maintain instrumentation and SOPs; keep electronic notebooks.

Skills

Mass spectrometry

Bioanalytical methods

Peptide mapping

Data analysis

Documentation

Tools

Sciex QTRAP

Sciex Q-TOF

Thermo Orbitrap Fusion/Lumos

MRM QQQ

Job description

Position Summary

Seeking a highly skilled and motivated Scientist/Sr. Scientist. The successful candidate will play a key role in supporting discovery stage programs with a particular focus on targeted protein degradation and next generation biologic therapeutics. The ideal candidate will possess extensive hands‑on experience in mass spec‑based bioanalysis, protein and peptide characterization, and analytical assay development. This is a cross‑functional role with significant impact on the research and development pipeline.

Key Responsibilities

• Lead the development, optimization, and fit for purpose validation of LC‑MS/MS assays and IP (hybrid ligand binding) assay for quantification of biomarkers, proteins, peptides, cytokines, and metabolites
• Design and execute workflows for peptide mapping, post‑translational modification (PTM) analysis, disulfide bond mapping, and glycosylation analysis
• Develop fit‑for‑purpose bioanalytical methods for proteins with complex attributes (e.g., high MW, high glycosylation, unexpected MWs) using advanced enzymatic digestion strategies
• Determine and communicate goals, timelines, and priorities for bioanalysis in cross‑functional project teams
• Conduct advanced data processing and statistical analysis using multiple software from different vendors
• Maintain and troubleshoot analytical instrumentation
• Maintain technical reports, SOP, and an electronic notebook

Required Qualifications

• Minimum of 5+ years of experience in mass spectrometry bioanalytical sciences
• Extensive experience with mass spectrometry analysis of proteins and peptides (Sciex QTRAP, Sciex Q-TOF, Thermo Orbitrap Fusion/Lumos, QQQ with MRM method)
• Demonstrated expertise in bioanalytical method development and validation of large molecule analytes
• Experience performing intact and subunit protein mass spectrometry analysis, including characterization of monoclonal antibodies, fusion proteins
• Hands‑on experience with a range of chromatography techniques RP‑HPLC, SEC, HILIC, nanoLC, microLC
• Proficient in wet lab sample preparation techniques (SPE, IP, LLE)
• Ability to maintain and troubleshoot mass spec instrumentation in close collaboration with vendors to ensure optimal system performance and uptime
• Excellent organizational skills and attention to detail
• Ability to balance multitasks with competing priorities
• Strong written and verbal communication skills

Work Environment

• Laboratory‑based position (based in Cambridge)
• Fast paced environment
• Collaboration with cross‑functional R&D and bioanalytical teams

Preferred Qualifications

• Experience with computational biology, bioinformatics
• Experience with biochemical, biophysical, biology assays such as SPR, TR‑FRET, ELISA, MSD
• Experience executing method development, validation, and assay transfer at CROs and external partners

Equal Opportunity

Beacon Hill is an equal opportunity employer and individuals with disabilities and/or protected veterans are encouraged to apply.

California residents: Qualified applications with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.

Benefits

• Medical, dental, vision, and federal and state leave programs as required by applicable agency regulations to those that meet eligibility.
• Upon successfully being hired, details will be provided related to our benefit offerings.

Company Profile

Founded by industry leaders to set a new standard in search, career placement and flexible staffing, we deliver coordinated staffing solutions with unparalleled service, a commitment to project completion and success and a passion for innovation, creativity and continuous improvement. Our niche brands offer a complete suite of staffing services to emerging growth companies and the Fortune 500 across market sectors, career specialties/disciplines and industries. Over time, office locations, specialty practice areas and service offerings will be added to address ever changing constituent needs. Learn more about Beacon Hill and our specialty divisions, Beacon Hill Associates, Beacon Hill Financial, Beacon Hill HR, Beacon Hill Legal, Beacon Hill Life Sciences and Beacon Hill Technologies by visiting www.bhsg.com.

We look forward to working with you! Beacon Hill. Employing the Future™