Scientist III - Large Molecule (LC/MS)

BioAgilytix; United States; On-site; USD 80,000 - 110,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

401k with Employer Match

Paid Time Off

Employee Referral Program

Job summary

A leading bioanalytical service provider in the United States is seeking a Scientist III to oversee all aspects of bioanalytical studies while ensuring compliance with regulations. The role requires a deep expertise in method development using chromatography and mass spectrometry, emphasizing client management and project execution. Ideal candidates will have extensive experience in a laboratory setting, strong analytical skills, and the ability to lead junior staff. Competitive benefits and a commitment to professional growth are offered.

Qualifications

• Minimum 12 years of experience in a scientific laboratory environment with a Bachelor's degree.
• Knowledge of regulatory guidance and industry best practices for LC/MS.
• Advanced capabilities in data analysis and visualization.

Responsibilities

• Oversee bioanalytical studies and project management.
• Act as the primary client contact and present data.
• Lead assay development for biologics and biomarkers.

Skills

Chromatographic assay development

Mass spectrometry expertise

Regulatory compliance (GxP)

Team collaboration

Effective communication

Education

Bachelor's degree in molecular biology or related field

Master's degree in molecular biology or related field

PhD in molecular biology or related field

Tools

Microsoft Word

Microsoft Excel

Sciex OS/Analyst

Watson LIMS

Job description

At BioAgilytix, we are passionate about premier science and the impact it has on our world. Our team of highly experienced scientists and professionals deliver tailored services for supporting new medicine breakthroughs with best‑in‑class bioanalytical services. We are tirelessly committed to our customers by being solution‑oriented and deadline‑driven, and we are growing. Our culture is fast‑paced, fun and never boring. Because we work across numerous clients and drug modalities, your career can develop rapidly. You’ll gain experience with a variety of challenges all while you enable life‑changing, life‑saving therapeutics to the patients who need them.

Our Liquid Chromatography/Mass Spectrometry (LC/MS) team is seeking a Scientist III to serve as Bioanalytical Project Manager (BPM)/Principal Investigator (PI), overseeing all aspects of bioanalytical studies—including project scope definition, proposal preparation, timelines, scheduling, budget, and revenue management. This role is best suited for someone with deep expertise in method development, GxP‑compliant validation, and both targeted and untargeted analysis using chromatography and mass spectrometry, combined with strong communication skills and the confidence to engage with external clients.

At our organization, we’re dedicated to pushing the boundaries of analytical science. Our LC/MS team leverages the synergy between liquid chromatography (LC) and mass spectrometry (MS) to revolutionize how we understand and quantify compounds in complex samples. With a steadfast commitment to excellence and innovation, we tackle challenges across the spectrum of drug discovery to clinical diagnostics, driving advancements that shape the future of healthcare.

Essential Responsibilities

• Serve as Bioanalytical Project Manager (BPM)/Principal Investigator (PI), overseeing all aspects of bioanalytical studies including project scope definition, proposal preparation, timelines, scheduling, budget, and revenue management.
• Act as primary client contact, presenting data, ensuring clear communication, and aligning project deliverables with client timelines and expectations.
• Lead assay development, validation, and sample analysis of biologics, proteins, peptides, ADCs, and/or biomarkers using chromatographic and mass spectrometric (LC/MS) techniques in support of preclinical, clinical, and product release studies.
• Design, plan, and execute experiments independently; troubleshoot assays; analyze and interpret data; prepare summary tables, plans, reports, and SOPs.
• Ensure GLP compliance throughout assay development, validation, and sample analysis activities, including prompt identification and notification of deviations and preparation of associated documentation.
• Set up and manage studies in LIMS; maintain accurate laboratory records, worksheets, and raw data with peer review.
• Train, mentor, and direct junior scientists and analysts, including preparing and reviewing scientific training materials.
• Provide scientific leadership by planning experimental designs for junior staff and driving bioanalytical projects to successful completion.

Additional Responsibilities

• Other duties as needed.

Minimum Preferred Qualifications – Education/Experience (Scientist III)

• Bachelor’s degree in molecular biology, biochemistry, immunology, biotechnology, or related field with not less than 12 years’ experience in a scientific laboratory environment; or
• Master’s degree in molecular biology, biochemistry, immunology, biotechnology, or related field with not less than ten (10) years’ experience in a scientific laboratory environment; or
• PhD in molecular biology, biochemistry, immunology, biotechnology, or related field with not less than eight (8) years’ experience in a scientific laboratory environment.
• Knowledge of regulatory guidance and industry best practices for LC/MS, and other large molecule assays.
• Demonstrated expertise in developing chromatographic and mass spectrometric assays including LC/MS and LC/MS/MS for bioanalytical studies by extracting analytes of interest from complex biological matrices using protein precipitation, liquid‑liquid, solid phase, immunoprecipitation or other extraction technique.
• Advanced capabilities in data analysis, data visualization, statistical analysis.
• Proficiency with Microsoft Word, Excel, Sciex OS/Analyst, MassLynx, XCalibur, Chromeleon, Watson LIMS, JMP, GraphPad Prism.
• Familiarity with GDP, GLP, GCLP, GCP.

Minimum Preferred Qualifications – Skills

• Experience with development, validation and execution of chromatographic and mass spectrometric assays (LC/MS), and/or ability to perform most tasks associated with custom research planning and bench work.
• Must work effectively within team to meet objectives under time constraints.
• A knack for designing efficient and impactful experiments.
• Experience working in a regulated environment, with a thorough understanding of GDP, GLP, GCLP, GCP.
• Independence, enthusiasm, openness, and adaptability.
• Demonstrated effective communication skills.
• The ability to inspire others to do their best work and drive results.
• Excellent customer service skills (internal and external).

Working Environment

• Primarily laboratory environment.
• Exposure to biological fluids with potential exposure to infectious organisms.
• Rare exposure to skin and lung irritants, toxic materials, and hazardous waste.
• Personal protective equipment required, such as protective eyewear, garments, and gloves.
• Routinely uses standard office equipment such as computers, phones, photocopiers, and filing cabinets.

Physical Demands

• Ability to work in an upright and/or stationary position for up to eight (8) hours per day.
• Repetitive hand movement of both hands with the ability to make fast, simple, repeated movements of the fingers, hands, and wrists to operate lab equipment.
• Frequent mobility needed.
• Frequent crouching, stooping, with frequent bending and twisting of upper body and neck.
• Light to moderate lifting and carrying (or otherwise moves) objects including laboratory equipment, laboratory supplies, and laptop computer with a maximum lift of 20 pounds.
• Ability to access and use a variety of computer software.
• Ability to communicate information and ideas so others will understand, with the ability to listen to and understand information and ideas presented through spoken words and sentences.
• Frequently interacts with others to obtain or relate information to diverse groups.
• Requires multiple periods of intense concentration.
• Performs a wide range of variable tasks as dictated by variable demands and changing conditions with little predictability as to the occurrence.
• Ability to perform under stress and multi‑task.
• Regular and consistent attendance.

Position Type and Expected Hours of Work

• This is a full‑time position.
• Some flexibility in hours is allowed, but the employee must be available during the “core” work hours as published in the BioAgilytix Employee Handbook.
• Occasional weekend, holiday, and evening work required.
• Occasional travel required.

Benefits And Other Perks

Medical Insurance (HDHP with HSA; PPO), Dental Insurance, Vision Insurance, Flexible Spending Account (medical; dependent care), Short Term Disability | Long Term Disability Life Insurance, Paid Time Off (4 weeks per year), Parental Leave, Paid Holidays (9 scheduled; 5 floating), 401k with Employer Match, Employee Referral Program.

COMMITMENT TO EQUAL OPPORTUNITY

BioAgilytix provides equal employment opportunities to all employees and applicants for employment without regard to race, color, ancestry, national origin, gender, sexual orientation, marital status, religion, age, disability, gender identity, results of genetic testing, service in the military, or any other group protected by federal, state, or local law.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.