Rare Disease Biology Scientist: Target Discovery & iPSC

BioSpace; Thousand Oaks (CA); On-site; USD 130,000 - 170,000; Full time

Job summary

Amgen is seeking a Scientist, Rare Disease Biology in Thousand Oaks, CA to advance discovery of therapies for rare diseases. You will design and execute in vitro/ex vivo studies, generate data to support target identification, and collaborate with disease biologists, computational scientists, and translational teams.

Strong emphasis on iPSC-derived models and gene-editing technologies. The role requires a PhD or equivalent with experience in neurobiology, cellular models, and cross-functional

Qualifications

• PhD or equivalent higher degree with a strong research background in relevant biology.
• Experience in neuroscience or related therapeutic areas is required.
• Experience with human cellular models and advanced in vitro methods.

Responsibilities

• Contribute to discovery and advancement of therapies for rare diseases as a core team member.
• Design, execute, and interpret in vitro and ex vivo studies to test therapeutic hypotheses.
• Generate high-quality data to support target identification and progression of programs.
• Investigate molecular/cellular mechanisms including transcriptional dysregulation and protein aggregation.
• Establish scalable experimental platforms supporting multiple programs.
• Integrate experimental findings with literature, genetics, and clinical observations.
• Collaborate with scientists across biology, computation, translational research and partners.

Skills

Neurobiology experience

Genetic disease biology

iPSC-derived models

Neuronal differentiation

Patient-derived cellular models

CRISPR/gene editing

Computational biology

Collaborative research

Education

PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline

Master's degree + 3 years of scientific research experience

Bachelor's degree + 5 years of scientific research experience

Job description

Amgen is seeking a Scientist, Rare Disease Biology in Thousand Oaks, CA to advance discovery of therapies for rare diseases. You will design and execute in vitro/ex vivo studies, generate data to support target identification, and collaborate with disease biologists, computational scientists, and translational teams.

Strong emphasis on iPSC-derived models and gene-editing technologies. The role requires a PhD or equivalent with experience in neurobiology, cellular models, and cross-functional