Scientist, Rare Disease Biology

Amgen; Thousand Oaks (CA); On-site; USD 115,000 - 156,000; Full time

Job summary

Amgen in Thousand Oaks seeks a Scientist, Rare Disease Biology to advance discovery and progression of therapies for rare diseases. You will lead in vitro and ex vivo studies, develop human cellular disease models, including iPSC-based systems, and integrate data from genetics, literature, and clinical observations to inform portfolio decisions.

As a core member of multidisciplinary teams, you will balance rigorous science with urgency, contribute to target identification, and present findings

Qualifications

• PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related field, OR Master's with 3+ years of research.
• Bachelor's with 5+ years of research experience.

Responsibilities

• Contribute to discovery and advancement of therapies for rare diseases using in vitro and ex vivo studies.
• Develop and apply human cellular models, including iPSC-based systems, to support discovery efforts.
• Integrate experimental findings with literature, genetics, and clinical observations to inform decisions.
• Collaborate with disease biologists, computational scientists, and translational researchers.
• Present findings to project teams and governance forums.

Skills

Neurobiology

Genetic disease biology

iPSC-derived models

CRISPR/Gene editing

Computational biology

Education

PhD in Immunology/Neurology/Cell Biology

Master's degree + 3 years research

Bachelor's degree + 5 years research

Tools

CRISPR tools

Organoid models

Job description

Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Position:

Scientist, Rare Disease Biology

What you will do:

Let’s do this. Let’s change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases by serving as a core member of multidisciplinary disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform portfolio decisions. This role offers a unique opportunity to establish and leverage advanced human cellular disease models, including iPSC-based systems, to support discovery efforts across rare diseases. Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses. Generate high-quality experimental data to support target identification, validation, and progression of rare disease research programs. Investigate molecular and cellular mechanisms associated with transcriptional dysregulation, protein aggregation, cellular stress responses, and impairment of neurological and neuromuscular processes. Establish scalable experimental platforms that can support multiple rare disease programs. Integrate experimental findings with published literature, human genetics, clinical observations, and other data sources to develop mechanistic insights and inform scientific decision-making. Serve as an active member of disease-focused research pods, collaborating closely with disease biologists, computational scientists, translational researchers, and partner functions. Participate in scientific discussions, target reviews, and portfolio evaluations by contributing data-driven insights and recommendations. Build and maintain productive relationships with internal and external collaborators, including academic partners, foundations, and scientific experts when appropriate. Present scientific findings and recommendations to project teams, governance forums, and departmental meetings. Maintain accurate documentation and contribute to organizational knowledge-sharing efforts. Embrace and contribute to a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Scientist with the following qualifications:

Basic Qualifications

• PhD in Immunology, Neurology, Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related discipline OR Master's degree and 3 years of scientific research experience
• Bachelor's degree and 5 years of scientific research experience

Preferred Qualifications

• Experience in neurobiology, genetic disease biology, or related therapeutic areas
• Experience studying mechanisms associated with protein aggregation, RNA toxicity, gene silencing, cellular stress responses, or neurological and neuromuscular disease processes
• Demonstrated expertise developing, maintaining, and utilizing iPSC-derived cellular models
• Experience with neuronal differentiation, glial cell systems, organoid models, or other advanced human cellular systems
• Experience working with patient-derived cellular models and genetically engineered cellular systems
• Familiarity with CRISPR-based approaches, gene editing, or functional genomics technologies is desirable
• Scientific curiosity and enthusiasm for exploring emerging disease areas and technologies
• Demonstrated ability to combine experimental and computational approaches to scientific problem-solving
• Experience working effectively within highly collaborative and matrixed research environments
• Ability to balance scientific rigor with urgency and adaptability in a dynamic research environment
• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement
• Familiarity with AI-enabled scientific tools, image analysis workflows, computational biology approaches, or advanced data analytics

What you can expect of us

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

• Salary Range 115,393.45USD -156,120.55 USD
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Refer to the Work Location Type in the job posting to see if this applies.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen