Senior Scientist, Functional Genomics & Genome Engineering

Amgen; Thousand Oaks (CA); Hybrid; USD 127,000 - 172,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental & vision coverage

Life and disability insurance

Flexible spending accounts

Stock-based incentives

Generous paid time off

Job summary

Amgen in Thousand Oaks, CA is seeking a Senior Scientist in Functional Genomics to develop and apply genome engineering technologies that accelerate target discovery and deepen our understanding of disease biology.

You will design and optimize AAV and lentiviral vectors, apply CRISPR-based perturbations in vitro and in vivo, and collaborate across biology, computational biology, chemistry and therapy areas to translate advances into therapeutics.

Qualifications

• PhD in Molecular Biology, Cell Biology, Genetics, Bioengineering, Virology, or related field.
• Strong background in molecular biology, genome engineering, CRISPR technologies, and functional genomics.
• Demonstrated expertise in design, engineering, production, optimization, and characterization of AAV and/or lentiviral vectors.

Responsibilities

• Develop and implement next-generation viral vector platform and genome engineering technologies to expand functional genomics capabilities and accelerate target discovery.
• Design, engineer, produce, optimize, and characterize AAV and lentiviral vectors for genetic perturbation applications, including gene overexpression and CRISPR-based genome engineering, in vitro and in vivo models.
• Design and execute innovative molecular biology and functional genomics experiments supporting target discovery, validation, and mechanistic studies.
• Design, execute, analyze, and interpret experimental studies, communicating findings to multidisciplinary discovery teams.
• Evaluate and implement emerging technologies in genome engineering, viral vector engineering, and functional genomics to enhance discovery capabilities.
• Collaborate with scientists across biology, computational biology, chemistry, and therapeutic areas to solve challenging biological problems.

Skills

Molecular biology

Genome engineering

CRISPR technologies

Functional genomics

Collaborative problem solving

Education

PhD in Molecular Biology/Genetics/Bioengineering/Virology

Post‑doc or industry experience

Tools

AAV vectors

Lentiviral vectors

Genomic perturbation tools

Job description

Amgen in Thousand Oaks, CA is seeking a Senior Scientist in Functional Genomics to develop and apply genome engineering technologies that accelerate target discovery and deepen our understanding of disease biology.

You will design and optimize AAV and lentiviral vectors, apply CRISPR-based perturbations in vitro and in vivo, and collaborate across biology, computational biology, chemistry and therapy areas to translate advances into therapeutics.