QSP Postdoc: AI-Driven PK/PD Modeling

Scorpion Therapeutics

Indianapolis (IN)

On-site

USD 58,000 - 123,000

Full time

14 days+

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Benefits offered by this job

401(k)

Medical/Dental/Vision coverage

Life insurance

Time off

Job summary

Scorpion Therapeutics in the United States seeks a Postdoctoral scientist (Global PKPD) to develop Quantitative Systems Pharmacology (QSP) models and apply AI-powered approaches to integrate biology, pharmacology, and preclinical/clinical data.

You will design ODE-based QSP structures capturing drug PK, target biology, and cellular/physiological dynamics; perform parameter estimation and simulations; and collaborate with cross-functional teams to inform dosing strategies and translational

Qualifications

PhD in quantitative pharmacology, systems biology, biomedical engineering, applied mathematics, or related field.
Experience developing QSP/mechanistic PKPD or ODE-based biological system models.
Experience developing virtual patient populations.
Proficiency in modeling software such as R, Matlab/Simbiology, Python, NONMEM, Monolix, or related tools.
Experience with parameter estimation and sensitivity analysis.
Authorized to work in the United States full-time; Lilly does not sponsor visas/work authorization.

Responsibilities

Conduct literature, regulatory, and database searches to compile preclinical/clinical data for model design and parameterization.
Design and implement ODE-based QSP model structures capturing drug PK, target/receptor biology, and cellular/physiological dynamics.
Perform parameter estimation, simulations, and model analysis to support timely drug discovery/development decisions.
Use validated models to generate insights for dosing strategies, risk stratification, and translational/clinical questions.
Communicate results to technical and non-technical audiences; collaborate cross-functionally.
Maintain documentation; present at scientific conferences; author peer-reviewed articles.