Associate Director, QSP Strategy & Modeling

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics is seeking an Associate Director of Quantitative Systems Pharmacology to support a portfolio of RNAi therapeutics. The role applies systems pharmacology, clinical pharmacology, PK/PD, and data analysis to answer drug development questions across all stages.

You will lead QSP modeling efforts, partner with pharmacology and modeling teams, and mentor others while publishing and presenting findings to advance development decisions.

Qualifications

• Ph.D. (or equivalent) in a quantitative field such as applied mathematics, biomedical engineering, systems biology/pharmacology.
• Minimum 5+ years in the pharmaceutical industry, consulting, or regulatory setting.
• Proven track record using QSP modeling to influence drug development decisions.

Responsibilities

• Strategize, formulate, and execute QSP modeling and simulation for dose selection and trial design.
• Partner with clinical pharmacologists and modelers to interpret data and guide QSP model building/refinement.
• Build and interpret QSP models to understand disease pathways and treatment effects.
• Analyze, interpret, and report results for internal decisions.
• Stay current on QSP methodologies; act as a technical leader and mentor.
• Increase visibility through publications and scientific presentations.

Skills

QSP modeling

Systems biology

PK/PD

Differential equations

Parameter estimation

Statistical analysis

Communication

Education

Ph.D. in applied mathematics, biomedical engineering, systems biology/pharmacology

Tools

R

MATLAB

SimBiology

Job description

Scorpion Therapeutics is seeking an Associate Director of Quantitative Systems Pharmacology to support a portfolio of RNAi therapeutics. The role applies systems pharmacology, clinical pharmacology, PK/PD, and data analysis to answer drug development questions across all stages.

You will lead QSP modeling efforts, partner with pharmacology and modeling teams, and mentor others while publishing and presenting findings to advance development decisions.