Principal Scientist, Protein Biophysics & Amyloid Research

Pioneering Medicines; Cambridge (MA); On-site; USD 163,000 - 215,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Labs 132 (FL132), based in Cambridge, MA, seeks a Principal Scientist to build its amyloid research platform. You will lead protein biophysics, chemical biology, and drug discovery efforts, producing assay-grade proteins and shaping experimental methods from day one.

The role requires a PhD with 8+ years in structural biology or related fields, strong data-driven mindset, and experience with aggregation kinetics. Excellent collaboration skills are essential in this hands-on position.

Qualifications

• PhD in structural/chemical biology, biochemistry, biophysics, physical chemistry or related field with 8+ years of experience.
• Hands-on recombinant protein expression, purification, and QC with aggregation-prone proteins.
• Deep expertise with kinetic assays of protein aggregation and global kinetic fitting.
• Familiarity with amyloid aggregation mechanisms, strain/seeding biology, and cofactor systems.
• Motivated team-player with strong organizational and communication skills.

Responsibilities

• Shape scientific and technical direction with leadership to build experimental methods and teams.
• Establish in-house production and QC of assay-grade recombinant amyloid proteins.
• Design and analyze amyloid aggregation experiments.
• Characterize amyloid aggregates via MS, NMR, AFM or related methods.
• Support cell-based assays for toxicity, seeding, and clearance.
• Evaluate inhibitors of amyloid aggregation and translate findings to cellular models.
• Manage CROs and collaborations with robust documentation practices.
• Drive project goals and present data to teams.

Skills

Recombinant protein expr.

Protein purification

Quality control

Kinetic assays

Amyloid aggregation

Team player

Communication skills

Education

PhD in structural/chemical biology or related

Tools

Mass spectrometry

NMR

Cryo-EM

AFM

Job description

Flagship Labs 132 (FL132), based in Cambridge, MA, seeks a Principal Scientist to build its amyloid research platform. You will lead protein biophysics, chemical biology, and drug discovery efforts, producing assay-grade proteins and shaping experimental methods from day one.

The role requires a PhD with 8+ years in structural biology or related fields, strong data-driven mindset, and experience with aggregation kinetics. Excellent collaboration skills are essential in this hands-on position.