Lead Scientist, Amyloid Biophysics & Structural Biology

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 163,000 - 215,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive

Retirement benefits

Other benefits

Job summary

Flagship Labs 132 (FL132) in Cambridge, MA seeks a Principal Scientist to help build an amyloid research platform from the ground up. This hands-on role sits at the interface of protein biophysics, chemical biology, and neurodegeneration, producing assay-grade amyloid proteins and developing rigorous aggregation assays.

The successful candidate will have a Ph.D. with 8+ years of experience, strong quantitative skills, and a track record of scientific and technical innovation, with the ability to

Qualifications

• Ph.D. in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or a related field.
• Hands-on recombinant protein expression, purification, and QC.
• Deep expertise with kinetic assays of protein aggregation; global kinetic fitting.

Responsibilities

• Contribute to scientific and technical direction; help build experimental methods and train the team.
• Establish in-house production and QC of recombinant amyloid proteins; seed-free monomer prep.
• Design and analyze amyloid aggregation experiments; measure kinetics.
• Characterize amyloid aggregates via MS, NMR, AFM; translate findings to cellular models.
• Support cell-based assays for amyloid toxicity, seeding and clearance.
• Evaluate inhibitors of amyloid aggregation; manage CROs and collaborations; ensure data turnaround.
• Drive key project goals and present insights at team meetings.

Skills

Protein expression & QC

Kinetic assays

Amyloid biology

Team collaboration

Scientific communication

Education

Ph.D. in structural/chemical biology or related field

Tools

Mass spectrometry

NMR

AFM

Job description

Flagship Labs 132 (FL132) in Cambridge, MA seeks a Principal Scientist to help build an amyloid research platform from the ground up. This hands-on role sits at the interface of protein biophysics, chemical biology, and neurodegeneration, producing assay-grade amyloid proteins and developing rigorous aggregation assays.

The successful candidate will have a Ph.D. with 8+ years of experience, strong quantitative skills, and a track record of scientific and technical innovation, with the ability to