Lead Scientist: Amyloid Biophysics & Protein Structure

Pioneering Medicines; Cambridge (MA); On-site; USD 163,000 - 215,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Other benefits

Job summary

Flagship Pioneering seeks a Principal Scientist to build an amyloid research platform from the ground up in Cambridge, MA. This hands-on role spans protein biophysics, chemical biology, structural biology and drug discovery, producing assay-grade amyloid proteins and qualifying rigorous assays.

The candidate will lead experimental strategy, train a team, coordinate CROs, and translate data into actionable insights for advancing therapies in amyloid diseases.

Qualifications

• PhD with 8+ years of experience in structural biology, biophysics, or related field.
• Hands-on recombinant protein expression, purification and QC with aggregation-prone proteins.
• Experience with kinetic assays and global kinetic-fitting of data.
• Familiarity with amyloid aggregation mechanisms and seeding biology.

Responsibilities

• Contribute to scientific and technical direction with leadership.
• Establish in-house production and QC of recombinant amyloid proteins.
• Design and analyze amyloid aggregation experiments and kinetics.
• Characterize amyloid aggregates via MS, NMR, AFM or related methods.
• Support cell-based assays for toxicity, seeding and clearance.
• Evaluate inhibitors and translate findings to cellular models.
• Manage CROs and academic collaborations with robust documentation.
• Drive project goals and present insights at team meetings.

Education

PhD in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or related field

Tools

NMR

Mass spectrometry

Cryo-EM

AFM

Protein expression

Protein purification

Job description

Flagship Pioneering seeks a Principal Scientist to build an amyloid research platform from the ground up in Cambridge, MA. This hands-on role spans protein biophysics, chemical biology, structural biology and drug discovery, producing assay-grade amyloid proteins and qualifying rigorous assays.

The candidate will lead experimental strategy, train a team, coordinate CROs, and translate data into actionable insights for advancing therapies in amyloid diseases.