Biochemistry & Lead Discovery Scientist I

Pioneering Medicines; Cambridge (MA); In loco; USD 100.000 - 127.000; Tempo pieno

Descrizione del lavoro

Flagship Pioneering's FL111 unit is seeking an independent Scientist I with deep expertise in biochemical and biophysical assay design to lead assay development, target engagement studies, and binding characterization for small molecules and related modalities in Cambridge, MA.

You will work closely with chemistry and biology, guide high-throughput assays, and contribute to hit-to-lead optimization while collaborating across functions in a fast-paced environment.

Competenze

• MS or PhD required in Biochemistry, Chemical Biology, Enzymology, or related field.
• 8+ years of relevant academic or industry experience (MS) or 0–2 years (PhD).
• Strong understanding of protein chemistry and biophysics; experience with small molecules.

Mansioni

• Lead biochemical assay development to monitor protein/ligand and protein/protein interactions.
• Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs.
• Drive protein purification and QC to support discovery efforts.
• Set up and run high-throughput assays, troubleshoot to keep programs moving.
• Partner with CROs to extend internal capacity.
• Collaborate cross-functionally and contribute scientific input across multiple projects.

Conoscenze

Biochemistry

Biophysics

Assay development

Protein chemistry

Formazione

MS or PhD in Biochemistry, Chemical Biology, Enzymology, or related field

Descrizione del lavoro

Flagship Pioneering's FL111 unit is seeking an independent Scientist I with deep expertise in biochemical and biophysical assay design to lead assay development, target engagement studies, and binding characterization for small molecules and related modalities in Cambridge, MA.

You will work closely with chemistry and biology, guide high-throughput assays, and contribute to hit-to-lead optimization while collaborating across functions in a fast-paced environment.