Principal Scientist, Process Modeling, Digital Insights

Scorpion Therapeutics; Cambridge (MA); Hybrid; USD 150,000 - 230,000; Full time

Job summary

Scorpion Therapeutics in the United States is seeking a Principal Scientist to lead physics-based engineering simulations within the Digital Insights team, optimizing bioprocess scale-up and technology transfer across biologics, small molecules, and other modalities.

You will conduct CFD and transport phenomena modeling of bioreactor operations, develop scale-down models, and provide technical leadership to drive CMC decisions. Hybrid US-based with ~10% travel.

Qualifications

• PhD or MS in engineering/physics with 6+ years pharma/industrial experience.
• Expertise in CFD and transport phenomena for bioprocess applications.
• Proven ability to validate models with experimental data.
• Strong scripting skills in Python and MATLAB.

Responsibilities

• Conduct CFD and transport phenomena modeling of bioreactor operations.
• Develop and validate scale-down models.
• Provide technical leadership and mentorship.
• Shape modeling standards and roadmaps.
• Support cross-functional teams with simulation insights for CMC decisions.

Skills

CFD tools

Transport phenomena

Bioprocess scale-up

Python

MATLAB

Education

Ph.D. or M.S. in Engineering/Physics

Tools

ANSYS Fluent

COMSOL

OpenFOAM

Job description

Role

Principal Scientist leading physics-based engineering simulation within the Digital Insights team to optimize bioprocess scale-up and technology transfer for biologics, small molecules, and other modalities.

Responsibilities

• conduct CFD and transport phenomena modeling of bioreactor mixing, gassing, and other unit operations
• develop and validate scale-down models
• provide technical leadership and mentorship
• shape modeling standards and roadmap
• support cross-functional teams with simulation insights to inform CMC decisions

Requirements

• Ph.D. or M.S. in engineering, physics, or related fields with 6+ to 8+ years of industrial/pharma experience
• expertise in CFD tools (e.g., ANSYS Fluent, COMSOL, OpenFOAM), transport phenomena, and bioprocess scale-up
• strong scripting skills (Python/MATLAB)
• proven ability to validate models against experimental data

Preferred

• experience in biologics, cell culture bioreactor scale-up, shear-sensitive biologics, single-use systems, multiphase modeling, and process development

High-Value

• biologics
• bioprocessing
• CFD
• scale-up/scale-down
• physics-based modeling
• process characterization
• engineering simulation

Work Setup

hybrid (US-based), with ~10% travel.