Associate Principal Scientist, Downstream Bioprocess Modeling, Digital Insights

Scorpion Therapeutics; Boston (MA); Hybrid; USD 150,000 - 230,000; Full time

Job summary

Scorpion Therapeutics is seeking an Associate Principal Scientist specializing in process modeling and analytics for biologics downstream purification. You will develop mechanistic models to guide resin selection, gradient design, scale-up, and robustness across modalities.

The role involves building calibrated models, planning parameter-estimation experiments, and translating outputs into manufacturing decisions, with mentorship of junior scientists. Hybrid work setup is offered.

Qualifications

• Ph.D. or MS in Chemical Engineering, Bioengineering, or related field with 3–7+ years of industrial experience.
• Expertise in chromatography modeling, transport phenomena, and biologics process development.

Responsibilities

• Build calibrated models in CADET or equivalent tools.
• Design experiments for parameter estimation.
• Translate model outputs into manufacturing decisions.
• Mentor junior scientists.

Skills

Chromatography modeling

Transport phenomena

Biologics process development

Education

Ph.D. or MS in Chemical Engineering, Bioengineering, or related field

Tools

CADET

Job description

Role

Role: Associate Principal Scientist specializing in process modeling and analytics within biologics downstream purification.

Objectives

Objectives: develop and validate mechanistic models for chromatography and adjacent unit operations to guide resin selection, gradient design, scale-up, and robustness across biologics modalities.

Responsibilities

• build calibrated models in CADET or equivalent tools
• design experiments for parameter estimation
• translate model outputs into manufacturing decisions
• and mentor junior scientists.

Qualifications

• Ph.D. or M.S. in Chemical Engineering, Bioengineering, or related field with 3-7+ years of industrial experience
• expertise in chromatography modeling, transport phenomena, and process development for biologics such as mAbs or viral vectors.

High-Value

• biologics, downstream process modeling, chromatography (ion exchange, HIC, affinity), viral clearance, scale-up, mechanistic simulation, decision support, and cross-functional collaboration

Work Setup

hybrid; no explicit travel requirements specified.