Principal Scientist, Genome-Engineered Cell Lines

Scorpion Therapeutics; Princeton (NJ); On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

Health coverage

Wellbeing programs

401(k)

Disability/life/insurance

Legal support

Paid time off

Flexible time off

Job summary

Scorpion Therapeutics seeks a scientist to design, engineer, and validate physiologically relevant cellular systems to drive drug discovery at our Princeton, NJ site.

You will develop advanced engineered models for Lead Discovery and Optimization and guide project teams to ensure alignment and translational impact, collaborating with internal groups and external partners to translate insights into innovative, research-driven solutions.

Qualifications

• Master's or PhD with relevant post-degree experience required.
• Experience with CRISPR genome engineering and delivery methods.
• Proven ability to design and validate cellular models for drug discovery.
• Experience with high-content imaging and bioinformatics.

Responsibilities

• Design, engineer, and validate cellular systems to enable drug discovery.
• Develop advanced engineered cellular models for Lead Discovery and Optimization.
• Guide project teams in model selection to ensure alignment.
• Collaborate with internal teams and external partners to translate insights into solutions.

Skills

Genome biology

CRISPR genome engineering

Gene delivery methods

Engineered cellular systems

High-content imaging

Genomic sequence analysis

AI-guided cell line engineering

Data interpretation

Cross-functional collaboration

Education

Master's degree in molecular biology, cell biology, bioengineering (or related)

PhD with 4+ years academic/industry experience

Tools

Lentiviral delivery

AAV delivery

Electroporation

Transposon systems

CRISPR delivery methods

Job description

Scorpion Therapeutics seeks a scientist to design, engineer, and validate physiologically relevant cellular systems to drive drug discovery at our Princeton, NJ site.

You will develop advanced engineered models for Lead Discovery and Optimization and guide project teams to ensure alignment and translational impact, collaborating with internal groups and external partners to translate insights into innovative, research-driven solutions.