Senior Scientist, Genomics & CNS Target Discovery

Scorpion Therapeutics; United States; On-site; USD 151,000 - 170,000; Full time

Job summary

Scorpion Therapeutics is seeking a Ph.D.-level scientist to lead CRISPR-based functional genomics efforts in CNS drug discovery, validating therapeutic hypotheses in vitro and in preclinical models.

The role involves using CRISPR/Cas9, CRISPRa, and CRISPRi for gene modulation, developing delivery methods, and collaborating with neuroscience, pharmacology, and translational teams; onsite work with competitive compensation.

Qualifications

• Ph.D. in Neuroscience, Molecular Biology, Genomics, or related field.
• 3+ years of functional genomics experience, industry CNS drug discovery preferred.
• Proficiency in CRISPR/Cas9, CRISPRa, and CRISPRi.
• In vivo CNS CRISPR delivery experience (AAV, lipids, electroporation).

Responsibilities

• Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical CNS models.
• Use CRISPR/Cas9, CRISPRa, CRISPRi to modulate gene expression in neuroanatomy contexts.
• Develop and optimize CRISPR delivery methods (viral and non-viral) for CNS gene editing.
• Establish and validate CRISPR-edited rodent models with molecular, cellular, and behavioral readouts.

Skills

CRISPR/Cas9

In vivo CNS delivery

Genomics data analysis

Behavioral phenotyping

Education

Ph.D. in Neuroscience/Molecular Biology/Genomics

Tools

Python

R

Unix CLI

AAV vectors

Job description

Scorpion Therapeutics is seeking a Ph.D.-level scientist to lead CRISPR-based functional genomics efforts in CNS drug discovery, validating therapeutic hypotheses in vitro and in preclinical models.

The role involves using CRISPR/Cas9, CRISPRa, and CRISPRi for gene modulation, developing delivery methods, and collaborating with neuroscience, pharmacology, and translational teams; onsite work with competitive compensation.