Lead Scientist, Genome-Engineered Cell Lines

Bristol-Myers Squibb; Princeton, Northern (NJ, KY); Hybrid; USD 136,000 - 165,000; Full time

Job summary

Bristol Myers Squibb in Princeton, NJ, is seeking a Principal Scientist for Cell Line Genome Engineering. You will design engineered cellular models to enable drug discovery, guide project teams in selecting models, and translate novel genome engineering approaches into scalable solutions across therapeutic areas.

The role emphasizes CRISPR-based editing, diverse cell systems, and collaboration with internal and external partners to maximize translational impact in a fast-paced environment.

Qualifications

• Advanced degree with 6+ years (MS) or 4+ years (PhD) in molecular/cellular biology or bioengineering.
• Proven expertise in genome engineering and cellular model development for drug discovery.
• Experience with iPSC-derived models and diverse cell lines is highly desirable.
• Strong publication record and ability to translate cutting-edge concepts into scalable solutions.
• Excellent communication and collaboration across matrixed teams.

Responsibilities

• Design and implement engineered cellular systems to support drug discovery.
• Lead cross-functional teams across sites to select appropriate cellular models.
• Apply and optimize CRISPR-based editing and gene delivery strategies.
• Collaborate with internal and external partners to translate insights into experiments.
• Integrate genomic, transcriptomic and phenotypic data to drive discovery decisions.

Skills

Genome biology

CRISPR editing

Cell line engineering

AI/ML for design

High-content imaging

Bioinformatics

Cross-functional leadership

Scientific communication

Education

Master’s degree in Molecular Biology/Cell Biology/Bioengineering

PhD in related field

Tools

CRISPR editing tools

Viral delivery systems

Next-generation sequencing

Transposon technologies

Job description

Bristol Myers Squibb in Princeton, NJ, is seeking a Principal Scientist for Cell Line Genome Engineering. You will design engineered cellular models to enable drug discovery, guide project teams in selecting models, and translate novel genome engineering approaches into scalable solutions across therapeutic areas.

The role emphasizes CRISPR-based editing, diverse cell systems, and collaboration with internal and external partners to maximize translational impact in a fast-paced environment.