Lead Scientist, Cell-Based Potency & MOA Analytics

Scorpion Therapeutics; Lexington (MA); On-site; USD 150,000 - 230,000; Full time

Benefits offered by this job

Medical/dental/vision

401(k) match

Disability insurance

Life insurance

Tuition reimbursement

Volunteer time off

Holidays

Well-being benefits

Sick time and vacation

Job summary

Scorpion Therapeutics in Lexington, MA is seeking a Senior/Principal Scientist to lead cell-based potency assay development across biologics programs, including qualification, validation, transfer, and lifecycle management. You will translate MOA insights into MOA-driven analytical methods and oversee mammalian cell culture and statistical analyses for product characterization and regulatory submissions.

The role also involves preparing documentation, coordinating with Process Development, QC,

Qualifications

• Ph.D./MS/BS with 3+/9+/11+ years of relevant experience as Senior/Principal
• Expertise in cell-based potency assays and MOA-driven methods for biologics/vaccines
• Advanced statistics for bioassays and proficiency with readouts (luminescence, ELISA, flow)

Responsibilities

• Provide technical leadership for cell-based potency assay development, qualification, validation, transfer, and lifecycle management across biologics programs.
• Translate MOA insights into phase-appropriate analytical methods supporting product characterization and regulatory submissions.
• Lead potency assays and mammalian cell culture work; perform statistical analysis and establish assay acceptance criteria.
• Prepare and review technical documentation (reports, SOPs, protocols, CMC/regulatory sections).
• Coordinate with cross-functional and external stakeholders and mentor team members.

Skills

Cell-based potency assays

MOA-driven methods

Biologics/regulatory experience

Statistical analysis

Mammalian cell culture

Flow cytometry

LIMS

Education

Ph.D.

MS

BS

Tools

ELN/LIMS

Job description

Scorpion Therapeutics in Lexington, MA is seeking a Senior/Principal Scientist to lead cell-based potency assay development across biologics programs, including qualification, validation, transfer, and lifecycle management. You will translate MOA insights into MOA-driven analytical methods and oversee mammalian cell culture and statistical analyses for product characterization and regulatory submissions.

The role also involves preparing documentation, coordinating with Process Development, QC,