Senior Scientist, Cell Line Genome Engineering

Bristol Myers Squibb; Princeton (NJ); On-site; USD 136,000 - 165,000; Full time

Job summary

Bristol Myers Squibb in Princeton, NJ, is seeking a Principal Scientist, Cell Line Genome Engineering to lead the design, engineering and validation of physiologically relevant cellular models to support drug discovery.

The candidate will drive CRISPR-based editing strategies, integrate AI-guided approaches, collaborate across therapeutic areas and global sites, and influence project teams toward scalable solutions that advance translational biology.

Qualifications

• Master’s degree in molecular biology, cell biology, bioengineering or related fields with 6+ years of experience OR PhD with 4+ years of experience.
• Demonstrated expertise in genome editing, cell line engineering and translational biology for drug discovery.

Responsibilities

• Design, engineer and validate physiologically relevant cellular models for drug discovery.
• Lead cross-functional teams across disciplines and locations to advance projects.
• Incorporate emerging technologies (AI/ML) to enhance experimental design and interpretation.

Skills

CRISPR genome engineering

Genome engineering

Cross-functional leadership

Data interpretation

Communication

AI-guided cell line engineering

Analytical thinking

Biology translation to discovery

Education

Master’s in Molecular Biology/Cell Biology/Bioengineering

PhD in Molecular Biology/Cell Biology/Bioengineering

Tools

CRISPR editors (Cas9/Cas12a)

Lentiviral/AAV delivery

Electroporation/Transposon delivery

NGS platforms (Illumina MiSeq/NextSeq)

Job description

Bristol Myers Squibb in Princeton, NJ, is seeking a Principal Scientist, Cell Line Genome Engineering to lead the design, engineering and validation of physiologically relevant cellular models to support drug discovery.

The candidate will drive CRISPR-based editing strategies, integrate AI-guided approaches, collaborate across therapeutic areas and global sites, and influence project teams toward scalable solutions that advance translational biology.