Principal Scientist, Biochemistry & Biophysics

C4 Therapeutics, Inc.; Watertown (MA); On-site; USD 150,000 - 230,000; Full time

Job summary

C4 Therapeutics is seeking a Lead Scientist to oversee biochemical and biophysical assay strategies for the early discovery of targeted protein degraders. The role involves designing and optimizing assays to characterize protein interactions and to drive compound prioritization in a fast-paced biotech setting.

The candidate will lead cross-functional project teams, manage CRO collaborations, and contribute to platform development, leveraging deep expertise in SPR, BLI, TR-FRET, and AlphaLISA to

Qualifications

• PhD in biochemistry, biophysics, or related field; 8+ years of post‑graduate experience in biotech/pharma, with expertise in protein–protein and protein–small molecule interactions, assay design, and data analysis.

Responsibilities

• Design and optimize assays to characterize protein interactions.
• Lead complex operational workstreams and interpret integrated data to inform compound prioritization.
• Serve as a scientific partner to project teams and manage CRO collaborations; contribute to platform development.

Skills

Protein interactions

Assay design

Data analysis

Cross-functional collaboration

Education

PhD in biochemistry/biophysics

Tools

SPR

BLI

TR-FRET

AlphaLISA

Job description

Role: Lead scientist overseeing biochemical and biophysical assay strategies for early discovery of targeted protein degraders at C4 Therapeutics.

Responsibilities:

design and optimize assays to characterize protein interactions, lead complex operational workstreams, interpret integrated data to inform compound prioritization, and serve as a scientific partner to project teams. Manage CRO collaborations and contribute to platform development.

Qualifications:

PhD in biochemistry, biophysics, or related field; 8+ years of post‑graduate experience in biotech/pharma, with expertise in protein–protein and protein–small molecule interactions, assay design, and data analysis.

High-Value:

focus on targeted protein degradation, molecular glues, heterobivalent degraders, with experience in biochemical/biophysical methods such as SPR, BLI, TR-FRET, AlphaLISA.

Preferred:

knowledge of structural biology, computational chemistry, proteomics, and cell pharmacology; experience managing projects and mentorship.

Work setup:

not specified, but involves cross-functional collaboration in a fast-paced biotech setting.