Senior Biochemistry & Biophysics Scientist - Degradation

ADP, Inc.; Watertown (MA); On-site; USD 185,000 - 204,000; Full time

Job summary

C4 Therapeutics in Watertown, MA, is seeking a Principal Scientist to lead the biochemistry and biophysics team, overseeing assay strategies for hit validation, lead optimization, and mechanism-of-action studies within targeted protein degradation programs.

The role combines hands-on lab work with matrixed management across Discovery, Biology, and Chemistry, guiding data interpretation, risk assessments, and program strategy while mentoring scientists and managing CRO collaborations.

Qualifications

• PhD in biochemistry, biophysics, or related field with extensive post-grad experience (8+ years).
• Proven expertise in quantitative characterization of protein interactions and small-molecule binding.
• Experience leading complex operations across multidisciplinary teams and driving discovery programs.

Responsibilities

• Provide scientific and operational leadership for biochemical/biophysical assay strategies supporting hit validation and lead optimization.
• Design and oversee assays to characterize protein–protein and protein–small molecule interactions and ternary complexes.
• Apply SPR, BLI, TR-FRET, AlphaLISA, and fluorescence polarization to generate high-quality data.
• Lead cross-functional workstreams with clear goals, timelines, and data quality expectations.
• Integrate data across assay formats to guide program strategy and compound prioritization.
• Serve as senior scientific partner to project teams and CROs, translating data into action.
• Mentor scientists and manage external collaborations, ensuring timely delivery and budgets.

Skills

Biochemistry

Biophysics

Protein interactions

Protein-small molecule interactions

Quantitative analysis

Project leadership

Cross-functional collaboration

Data integration

Education

PhD in Biochemistry/Biophysics

Tools

SPR

BLI

TR-FRET

AlphaLISA

Fluorescence polarization

CRO management

Job description

C4 Therapeutics in Watertown, MA, is seeking a Principal Scientist to lead the biochemistry and biophysics team, overseeing assay strategies for hit validation, lead optimization, and mechanism-of-action studies within targeted protein degradation programs.

The role combines hands-on lab work with matrixed management across Discovery, Biology, and Chemistry, guiding data interpretation, risk assessments, and program strategy while mentoring scientists and managing CRO collaborations.