Medicinal Chemistry Project Leader

Arvinas; New Haven (CT); Presencial; USD 180 000 - 280 000; Tempo integral

Resumo da oferta

Scorpion Therapeutics in New Haven, CT, seeks a Lead Medicinal Chemist to steer preclinical PROTAC programs and degrader-antibody conjugates toward clinical candidate nomination. You will design and synthesize PROTACs, analyze SAR and multivariate data, and collaborate with external CROs for synthesis and data needs, while providing strategic updates to senior leadership.

The role requires a PhD in organic or medicinal chemistry with 8+ years in pharma/biotech drug discovery and a track record

Qualificações

• PhD in organic or medicinal chemistry.
• 8+ years in pharma/biotech drug discovery.
• Extensive experience with antibody-drug conjugates and structure-based design.
• Strong understanding of pharmacokinetics and in vivo pharmacology.
• Proven project leadership and cross-functional communication skills.

Responsabilidades

• Lead design and synthesis of PROTACs and degrader-antibody conjugates.
• Analyze SAR and multivariate datasets to guide optimization.
• Collaborate with external CROs for synthesis and data needs.
• Provide strategic scientific updates to leadership.

Conhecimentos

Leadership

Cross-functional communication

Data analysis

Formação académica

PhD in organic or medicinal chemistry

Descrição da oferta de emprego

Role

Lead medicinal chemistry efforts for preclinical PROTAC projects, focusing on degrader-antibody conjugates, to guide programs toward clinical candidate nomination.

Responsibilities

design and synthesize PROTACs, analyze SAR and multivariate datasets, collaborate with external CROs for synthesis and data needs, and provide strategic scientific updates to leadership.

Requirements

PhD in organic or medicinal chemistry; 8+ years in pharma/biotech drug discovery; extensive experience with antibody-drug conjugates and structure-based design; strong understanding of pharmacokinetics and in vivo pharmacology; proven project leadership and cross-functional communication skills.

HighValue

expertise in PROTAC technology, antibody conjugates, structure-based optimization, pharmacokinetics, and preclinical decision-making.

WorkSetup

hybrid at New Haven, CT; onsite with flexible arrangements.