Associate Scientist, Post Doc Fellow- Quantitative Biosciences Early Discovery

Scorpion Therapeutics; Rahway (NJ); Hybrid; USD 80,000 - 110,000; Full time

Job summary

Scorpion Therapeutics in Rahway, NJ is seeking a Postdoctoral Research Fellow specializing in Quantitative Biosciences within Early Discovery to advance novel drug discovery methodologies such as chemically induced proximity.

The role involves leading mechanistic research using biophysical, biochemical, structural, and computational approaches to decode protein–small molecule interactions, collaborating across discovery chemistry, biology, and pharmacology, and authoring publications.

Qualifications

• Ph.D. with proven expertise in protein interaction assays (SPR, ITC, NMR) and protein biochemistry.
• Strong publication record demonstrated by authored papers.
• Experience with cross-disciplinary collaboration in drug discovery environments.

Responsibilities

• Lead mechanistic research using biophysical, biochemical, structural, and computational techniques to decode ternary systems and protein–small molecule interactions.
• Collaborate across discovery chemistry, biology, and pharmacology.
• Author publications and present findings.

Skills

Protein interactions

Biophysical methods

Biochemical methods

Structural biology

Computational modeling

Publications

Education

Ph.D. in Biochemistry/ Biophysics/ Pharmacology/ Structural Biology or related field

Tools

SPR

ITC

NMR

X-ray crystallography

cryo-EM

AI/ML structure prediction

Scripting

Job description

Postdoctoral Research Fellow

Specializing in Quantitative Biosciences within Early Discovery, focusing on novel drug discovery methodologies such as chemically induced proximity (e.g., molecular glues, PROTACs).

Responsibilities

• Lead mechanistic research using biophysical, biochemical, structural, and computational techniques to decode ternary systems and protein-small molecule interactions;
• Collaborate across discovery chemistry, biology, and pharmacology;
• Author publications and present findings.

Requirements

• Ph.D. in Biochemistry, Biophysics, Pharmacology, Structural Biology, or related field, with proven expertise in protein interaction assays (e.g., SPR, ITC, NMR), protein biochemistry, structural biology, and computational modeling;
• Strong publication record.

Preferred

• Experience with TPD platforms, high-resolution structural methods (X-ray, cryo-EM, NMR), AI/ML structure prediction tools, and scripting skills.

High Value

• Early-stage drug discovery, chemically induced proximity modalities, protein-ligand interaction characterization, structural biology, computational biophysics.

Work Setup

• Hybrid in Rahway, NJ, with approximately 10% travel.