Principal In Vivo Antibody Discovery Scientist

AbbVie; Worcester (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

AbbVie Bioresearch Center in Worcester, MA, seeks a Principal Scientist to lead in vivo antibody discovery. You will drive immunization-based discovery, provide strategic leadership across platforms, and mentor teams to identify high-quality therapeutic candidates for immunology, neuroscience, and oncology.

External collaborations and innovative AI-enabled approaches are encouraged to advance discovery. You will manage programs from hit to candidate nomination, align with cross-functional

Qualifications

• Typically 6+ years (PhD), 12+ (MS), or 14+ (BS) of industry experience.
• Hands-on expertise in antibody discovery platforms including hit identification and lead triage.
• Experience designing antigens and novel immunization strategies for challenging targets.
• Strong capability in leading discovery programs and cross-functional teams.

Responsibilities

• Lead antibody discovery programs from hit identification through candidate nomination.
• Design and implement antigen engineering and immunization strategies to maximize response.
• Provide technical leadership across multiple platforms including B cell and hybridoma.
• Lead identification of antibody and VHH modalities for diverse programs.
• Evaluate emerging technologies including AI/ML and automation to expand capabilities.
• Direct hybrid discovery campaigns with internal and external partners; manage risks.
• Mentor scientists and contribute to scientific reputation via publications and collaborations.

Skills

Antibody discovery

In vivo immunization

Leadership

Cross-functional collaboration

AI/ML in antibody discovery

Program management

Mentoring

Education

PhD in immunology or related field

MS in related field

Tools

B cell cloning

Immune repertoire screening

Hybridoma technology

VHH discovery

AI-enabled workflows

Job description

AbbVie Bioresearch Center in Worcester, MA, seeks a Principal Scientist to lead in vivo antibody discovery. You will drive immunization-based discovery, provide strategic leadership across platforms, and mentor teams to identify high-quality therapeutic candidates for immunology, neuroscience, and oncology.

External collaborations and innovative AI-enabled approaches are encouraged to advance discovery. You will manage programs from hit to candidate nomination, align with cross-functional