Principal Computational Biologist: AI Immunogenicity Leader

AbbVie Inc.; Lake Forest (CA); On-site; USD 250,000 - 350,000; Full time

Benefits offered by this job

Long-term incentives

Paid time off

Health insurance

401(k)

Job summary

AbbVie Inc. in Lake Forest, CA, seeks an accomplished scientific leader to advance AI-enabled computational immunology for biologics discovery and development.

You will define strategy, lead cross-functional programs, and build scalable computational capabilities across ADA risk assessment and translational modeling. You will mentor a team of computational scientists, collaborate with Discovery, Protein Sciences, Clinical, and Regulatory groups, and communicate results to senior leadership to

Qualifications

• PhD in computational biology or related field with typically 8+ years of experience; or a Master’s with typically 14+ years.
• Demonstrated discipline expertise in computational protein science, biologics discovery or development, AI/ML, and predictive modeling.
• Proven ability to define scientific strategy, lead multidisciplinary programs, and deliver impactful computational capabilities.
• Demonstrated people-management experience and ability to coach and develop personnel.
• Exceptional written, verbal, and presentation skills for diverse audiences.
• Strong collaboration and influence across internal and external groups.
• Experience with HLA binding prediction, T-cell epitope prediction, and single-cell analyses.

Responsibilities

• Lead development of AI/ML immunogenicity strategies and translational modeling.
• Integrate ADA, PK/PD, sequence, structure, and clinical data using machine learning.
• Apply protein language models and generative AI to identify immunogenicity drivers and design opportunities.
• Build computational frameworks linking in vitro/ex vivo assays to clinical outcomes.
• Communicate complex model results to both technical and non-technical teams.

Skills

AI/ML

Computational biology

Protein modeling

Systems immunology

Leadership

Communication

Education

PhD in computational biology

Master's degree with extensive experience

Tools

Python

PyTorch

TensorFlow

AWS

Databricks

Snowflake

Job description

AbbVie Inc. in Lake Forest, CA, seeks an accomplished scientific leader to advance AI-enabled computational immunology for biologics discovery and development.

You will define strategy, lead cross-functional programs, and build scalable computational capabilities across ADA risk assessment and translational modeling. You will mentor a team of computational scientists, collaborate with Discovery, Protein Sciences, Clinical, and Regulatory groups, and communicate results to senior leadership to