Principal AI Immunogenicity Scientist

AbbVie; Irvine (CA); On-site; USD 142,000 - 269,000; Full time

Job summary

AbbVie Inc. in Irvine, CA seeks a Computational Biologist Principal Research Scientist II to lead AI-enabled immunogenicity initiatives across biologics development. You will drive modeling, data integration, and translational strategies to mitigate immune liabilities.

The role combines protein language modeling, structure-based approaches, and multi-omics integration, with accountability for building a high-impact team and communicating results to senior leadership.

Qualifications

• Ph.D. in computational biology, computational structural biology, bioinformatics, biomedical informatics, computer science, data science, biophysics, or a related field with 8+ years of experience; or a Master’s with 14+ years.
• Demonstrated discipline expertise in computational protein science, biologics discovery or development, AI/ML, and predictive modeling.
• Proven ability to define scientific strategy, lead complex multidisciplinary programs, and deliver innovative computational capabilities.
• Demonstrated people-management experience, including leading scientific teams and coaching employees.
• Exceptional written, verbal, and presentation skills, with the ability to communicate clearly to scientific and senior-leadership audiences.

Responsibilities

• Develop and deliver the computational immunogenicity strategy aligned with Development Sciences priorities.
• Lead AI/ML-based immunogenicity and protein modeling efforts.
• Integrate multi-omics and clinical data using machine learning approaches.
• Lead generative AI and data-platform initiatives for knowledge integration.
• Collaborate across Discovery, Protein Sciences, Bioanalysis, Clinical, Regulatory, and Data Science teams.
• Provide leadership, mentoring, and career development for the computational team.

Skills

AI/ML in biology

Protein engineering

Translational modeling

Leadership

Cross-functional collaboration

Python

Education

PhD in computational biology or related field

Tools

Python

PyTorch

TensorFlow

scikit-learn

XGBoost

AWS

Job description

AbbVie Inc. in Irvine, CA seeks a Computational Biologist Principal Research Scientist II to lead AI-enabled immunogenicity initiatives across biologics development. You will drive modeling, data integration, and translational strategies to mitigate immune liabilities.

The role combines protein language modeling, structure-based approaches, and multi-omics integration, with accountability for building a high-impact team and communicating results to senior leadership.