Preclinical Oncology Research Scientist (In Vivo)

Novartis Group Companies; Cambridge (MA); On-site; USD 58,000 - 107,000; Full time

Benefits offered by this job

Hybrid work options

14 weeks paid parental leave

Insurance plans

Retirement plans

Job summary

Novartis Group Companies in Cambridge, USA is seeking a Scientist to lead preclinical in vivo oncology studies, integrating exposure, target engagement and pharmacodynamic responses to guide project decisions.

You will design dosing regimens, perform mouse studies, develop protein‑based assays (MSD/ELISA/Western blot) and analyze RNA data to inform cross‑functional teams. Strong independence and data interpretation are essential.

Qualifications

• Bachelor’s or Master’s degree in pharmacology, biology, cancer biology, molecular biology or related field.
• Industry or academic experience showing independence for Scientist role.
• Strong hands‑on mouse study experience including dosing and tumor implantation.
• Hands‑on experience with protein‑based assays (MSD/ELISA/Western blot).
• Ability to independently design, execute, analyze and troubleshoot in vivo pharmacology studies.

Responsibilities

• Independently design, plan and execute preclinical in vivo oncology studies.
• Perform mouse procedures including dosing, tumor implantation, monitoring and sampling.
• Establish tumor models for efficacy and PK/PD studies.
• Define study objectives and experimental strategies for dose selection and sampling.
• Develop protein‑based pharmacodynamic assays (MSD, ELISA, Western blot).
• Analyze RNA‑based gene expression alongside protein data for PD and biomarkers.
• Oversee tissue processing and assay workflows for reliable analyses.
• Integrate efficacy, exposure and PD data to evaluate exposure‑response relationships.
• Record experiments in electronic lab notebook.
• Present data and recommendations to cross‑functional teams.

Skills

In vivo pharmacology

Mouse studies

Protein-based assays

Data interpretation

Biomarker analysis

Education

Bachelor’s or Master’s in biology or related

Tools

MSD assays

ELISA

Western blot

Job description

Novartis Group Companies in Cambridge, USA is seeking a Scientist to lead preclinical in vivo oncology studies, integrating exposure, target engagement and pharmacodynamic responses to guide project decisions.

You will design dosing regimens, perform mouse studies, develop protein‑based assays (MSD/ELISA/Western blot) and analyze RNA data to inform cross‑functional teams. Strong independence and data interpretation are essential.